Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CACNA2D1 | P54289 | 7/20 | 0.42 |
| ▸ | CACNB1 | Q02641 | 7/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 6/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13355595 | 0.84 | KMT2A (0.44) | KMT2ACACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL3134253 | 0.76 | CACNA2D1 (0.43) | KMT2ACACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL13349262 | 0.76 | OPRD1 (0.44) | KMT2ACACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL13798018 | 0.75 | CACNA2D1 (0.42) | KMT2ACACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL13798112 | 0.74 | KMT2A (0.46) | KMT2ACACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL29785546 | 0.71 | KMT2A (0.49) | KMT2ACACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL3129358 | 0.70 | DRD2 (0.49) | KMT2ACACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL29785637 | 0.70 | DRD2 (0.49) | KMT2ACACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL13349263 | 0.70 | CACNA2D1 (0.44) | KMT2ACACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL3137205 | 0.70 | KMT2A (0.46) | KMT2ACACNA2D1CACNB1CACNA1BCACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090156577-A1 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156577-A1 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | NQO2, QRFPR, NQO1 | KMT2A 1652/4885CACNA2D1 1701/4885CACNB1 4221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.