Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | ABL1 | P00519 | 11/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6068056 | 0.88 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2ABL1PIK3CD | |
| SCHEMBL13798160 | 0.86 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2ABL1PIK3CD | |
| SCHEMBL3661653 | 0.85 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2ABL1PIK3CD | |
| SCHEMBL4496509 | 0.84 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2ABL1PIK3CD | |
| SCHEMBL1685098 | 0.83 | ABL1 (0.65) | NPC1RAB9ASMN1; SMN2ABL1PIK3CD | |
| SCHEMBL14824329 | 0.80 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2ABL1PIK3CD | |
| SCHEMBL3662009 | 0.78 | ABL1 (0.53) | NPC1RAB9ASMN1; SMN2ABL1PIK3CD | |
| SCHEMBL12997528 | 0.78 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2ABL1PIK3CD | |
| SCHEMBL3664440 | 0.77 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2ABL1PIK3CD | |
| SCHEMBL3662337 | 0.77 | ABL1 (0.58) | ABL1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231653-B1 | ANTIBACTERIAL CONDENSED THIAZOLES | BIOTA EUROPE LTD (GB) | 2013-04-03 | — | — | EP | disclosed |
| WO-2009074812-A1 | ANTIBACTERIAL CONDENSED THIAZOLES | PROLYSIS LTD (GB) | 2009-06-18 | — | — | WO | disclosed |