Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 14/20 | 0.65 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1282482 | 0.86 | ABL1 (0.68) | ABL1NPC1RAB9ASMN1; SMN2PIK3CA | |
| SCHEMBL13798157 | 0.83 | NPC1 (0.57) | ABL1NPC1RAB9ASMN1; SMN2PIK3CA | |
| SCHEMBL4496509 | 0.82 | NPC1 (0.69) | ABL1NPC1RAB9ASMN1; SMN2PIK3CA | |
| SCHEMBL14824329 | 0.78 | NPC1 (0.64) | ABL1NPC1RAB9ASMN1; SMN2PIK3CA | |
| SCHEMBL1282877 | 0.78 | ABL1 (0.83) | ABL1NPC1RAB9ASMN1; SMN2PIK3CA | |
| SCHEMBL3763117 | 0.78 | ABL1 (0.67) | ABL1PIK3CAPIK3CG | |
| SCHEMBL15260016 | 0.76 | ABL1 (0.59) | ABL1NPC1RAB9ASMN1; SMN2PIK3CA | |
| SCHEMBL16975342 | 0.76 | ABL1 (0.59) | ABL1NPC1RAB9ASMN1; SMN2PIK3CA | |
| SCHEMBL6068056 | 0.76 | NPC1 (0.57) | ABL1NPC1RAB9ASMN1; SMN2PIK3CA | |
| SCHEMBL3767021 | 0.76 | ABL1 (0.60) | ABL1PIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012045124-A1 | BACTERIA TOPOISOMERASE II INHIBITING 2-ETHYLCARBAMOYLAMINO-1, 3-BENZOTHIAZOL-5-YLS | BIOTA EUROPE LTD (GB) | 2012-04-12 | — | — | WO | disclosed |