Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.69 |
| ▸ | RAB9A | P51151 | 7/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.69 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.68 |
| ▸ | ABL1 | P00519 | 7/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.52 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.52 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14189671 | 0.89 | ABL1 (0.70) | NPC1RAB9ASMN1; SMN2DYRK1AABL1 | |
| SCHEMBL3664536 | 0.86 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2DYRK1AABL1 | |
| SCHEMBL3657208 | 0.85 | DYRK1A (0.69) | NPC1RAB9ASMN1; SMN2DYRK1AABL1 | |
| SCHEMBL15274383 | 0.85 | DYRK1A (0.74) | NPC1RAB9ASMN1; SMN2DYRK1APTPN1 | |
| SCHEMBL4496509 | 0.84 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2ABL1PIK3CA | |
| SCHEMBL14824329 | 0.83 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2ABL1PIK3CA | |
| SCHEMBL1842324 | 0.82 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2DYRK1AABL1 | |
| SCHEMBL130572 | 0.81 | DYRK1A (1.00) | NPC1RAB9ASMN1; SMN2DYRK1APTPN7 | |
| Hydrochloric Acid SCHEMBL1844043 | 0.81 | NPC1 (0.97) | NPC1RAB9ASMN1; SMN2DYRK1AABL1 | |
| SCHEMBL13562821 | 0.80 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2DYRK1AABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231653-B1 | ANTIBACTERIAL CONDENSED THIAZOLES | BIOTA EUROPE LTD (GB) | 2013-04-03 | — | — | EP | disclosed |
| WO-2009074812-A1 | ANTIBACTERIAL CONDENSED THIAZOLES | PROLYSIS LTD (GB) | 2009-06-18 | — | — | WO | disclosed |