Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.69 |
| ▸ | RAB9A | P51151 | 4/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.69 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.68 |
| ▸ | ABL1 | P00519 | 8/20 | 0.59 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13798182 | 0.86 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2DYRK1AABL1 | |
| SCHEMBL3657208 | 0.85 | DYRK1A (0.69) | NPC1RAB9ASMN1; SMN2DYRK1AABL1 | |
| SCHEMBL4496509 | 0.84 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2ABL1PIK3CA | |
| SCHEMBL1842324 | 0.82 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2DYRK1AABL1 | |
| SCHEMBL16992945 | 0.81 | DYRK1A (1.00) | NPC1RAB9ASMN1; SMN2DYRK1A | |
| SCHEMBL31060991 | 0.81 | DYRK1A (1.00) | NPC1RAB9ASMN1; SMN2DYRK1A | |
| SCHEMBL14824329 | 0.81 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2ABL1PIK3CA | |
| Hydrochloric Acid SCHEMBL1844043 | 0.81 | NPC1 (0.97) | NPC1RAB9ASMN1; SMN2DYRK1AABL1 | |
| SCHEMBL13562821 | 0.80 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2DYRK1AABL1 | |
| SCHEMBL3664440 | 0.80 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2ABL1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8299065-B2 | Antibacterial condensed thiazoles | BIOTA EUROPE LTD. (GB) | 2012-10-30 | — | — | US | disclosed |
| US-8299065-B2 | Antibacterial condensed thiazoles | BIOTA EUROPE LTD. (GB) | 2012-10-30 | — | — | US | disclosed |
| US-20100305067-A1 | ANTIBACTERIAL CONDENSED THIAZOLES | BIOTA EUROPE LTD (GB) | 2010-12-02 | — | — | US | disclosed |
| US-20100305067-A1 | ANTIBACTERIAL CONDENSED THIAZOLES | BIOTA EUROPE LTD (GB) | 2010-12-02 | — | — | US | disclosed |
| EP-2231653-A1 | ANTIBACTERIAL CONDENSED THIAZOLES | Biota Europe Ltd (GB) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009074812-A1 | ANTIBACTERIAL CONDENSED THIAZOLES | PROLYSIS LTD (GB) | 2009-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305067-A1 | ANTIBACTERIAL CONDENSED THIAZOLES | NEK6, NEK1, TXK | NPC1 2672/4885RAB9A 2295/4885SMN1; SMN2 3360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.