Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 4/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.40 |
| ▸ | HAT1 | O14929 | 2/20 | 0.40 |
| ▸ | EP300 | Q09472 | 2/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2770023 | 0.88 | HCRTR1 (0.42) | HCRTR2HCRTR1PTGS2HAT1EP300 | |
| SCHEMBL2770132 | 0.84 | ABCB1 (0.44) | ABCB1PTGS1PTGS2PTGDR2ALDH1A1 | |
| SCHEMBL2769434 | 0.79 | PTGDR2 (0.41) | HCRTR2HCRTR1ABCB1PTGS1PTGS2 | |
| SCHEMBL13800532 | 0.74 | ABCB1 (0.45) | ABCB1PTGS1PTGS2PTGDR2NPSR1 | |
| SCHEMBL2585096 | 0.73 | HCRTR2 (0.74) | HCRTR2HCRTR1PTGS2PTGDR2ALDH1A1 | |
| SCHEMBL2770435 | 0.71 | ALDH1A1 (0.40) | PTGDR2ALDH1A1MEN1KMT2ACYP2C9 | |
| SCHEMBL2594270 | 0.71 | HCRTR2 (0.75) | HCRTR2HCRTR1PTGDR2NPSR1ALDH1A1 | |
| SCHEMBL4635639 | 0.70 | HCRTR1 (0.47) | HCRTR2HCRTR1ABCB1PTGS1PTGS2 | |
| SCHEMBL2770449 | 0.67 | ACLY (0.44) | PTGS2NPSR1ALDH1A1LMNAMAPT | |
| SCHEMBL10580913 | 0.65 | TBXA2R (0.58) | PTGDR2ALDH1A1LMNANPC1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090163534-A1 | Indolizine Derivatives | ARGENTA DISCOVERY LIMITED (GB) | 2009-06-25 | — | — | US | disclosed |
| US-20090163534-A1 | Indolizine Derivatives | ARGENTA DISCOVERY LIMITED (GB) | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163534-A1 | Indolizine Derivatives | HRH4, HRH2, NR1H2 | HCRTR2 14/4885HCRTR1 40/4885ABCB1 1910/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.