Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C4 | P17516 | 2/20 | 0.78 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.78 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.78 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.78 |
| ▸ | SERPINE1 | P05121 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | ALB | P02768 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | WDR5 | P61964 | 1/20 | 0.58 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.57 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.57 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.56 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.56 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.56 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.56 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.56 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12834030 | 0.86 | MEN1 (0.64) | AKR1C4AKR1C3AKR1C2AKR1C1LMNA | |
| SCHEMBL13802452 | 0.85 | AKR1C2 (0.78) | AKR1C4AKR1C3AKR1C2AKR1C1ALB | |
| SCHEMBL6349484 | 0.85 | AKR1C4 (0.78) | AKR1C4AKR1C3AKR1C2AKR1C1SERPINE1 | |
| SCHEMBL28586381 | 0.85 | KMT2A (0.66) | AKR1C4AKR1C3AKR1C2AKR1C1LMNA | |
| SCHEMBL28595259 | 0.84 | RAB9A (0.67) | AKR1C4AKR1C3AKR1C2AKR1C1LMNA | |
| SCHEMBL28581602 | 0.84 | WDR5 (0.62) | AKR1C4AKR1C3AKR1C2AKR1C1LMNA | |
| SCHEMBL399870 | 0.84 | MEN1 (0.68) | AKR1C4AKR1C3AKR1C2AKR1C1LMNA | |
| SCHEMBL16431064 | 0.82 | KMT2A (0.68) | AKR1C4AKR1C3AKR1C2AKR1C1LMNA | |
| SCHEMBL16496264 | 0.82 | SERPINE1 (0.76) | AKR1C4AKR1C3AKR1C2AKR1C1SERPINE1 | |
| SCHEMBL28588057 | 0.81 | MEN1 (0.69) | LMNAMEN1KMT2AWDR5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090155903-A1 | PHARMACEUTICAL COMPOSITION AND METHOD | MYRIAD GENETICS, INCORPORATED (US) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090155903-A1 | PHARMACEUTICAL COMPOSITION AND METHOD | APP, PSEN2, PSEN1 | AKR1C4 1211/4885AKR1C3 570/4885AKR1C2 653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.