Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 6/20 | 0.32 |
| ▸ | HTR2C | P28335 | 5/20 | 0.32 |
| ▸ | HTR2B | P41595 | 5/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22155162 | 0.77 | IDO1 (0.39) | IDO1HSPA5SIGMAR1LMNAPYCR1 | |
| SCHEMBL20669921 | 0.77 | HTR2A (0.30) | HTR2AHTR2CSLC6A4KCNH2 | |
| SCHEMBL14044235 | 0.74 | RAPGEF4 (0.33) | RAPGEF4MEN1KMT2A | |
| SCHEMBL13210657 | 0.72 | ADRB2 (0.38) | RAPGEF4HTR2AHTR2CHTR2BKMT2A | |
| SCHEMBL257057 | 0.71 | DAO (0.48) | IDO1SIGMAR1LMNAPYCR1FFAR4 | |
| SCHEMBL257060 | 0.71 | IDO1 (0.61) | IDO1LMNAPYCR1RAPGEF4S1PR1 | |
| SCHEMBL22379946 | 0.70 | HSPA5 (0.53) | HSPA5LMNACYP3A4MEN1ALDH1A1 | |
| SCHEMBL5251032 | 0.69 | HSPA5 (0.38) | IDO1HSPA5SIGMAR1PYCR1AR | |
| SCHEMBL10618084 | 0.67 | HTR2A (0.33) | SIGMAR1HTR2AHTR2CHTR2BCYP3A4 | |
| SCHEMBL1768628 | 0.67 | PDE2A (0.40) | RAPGEF4CYP3A4ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547694-B2 | Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-06-16 | — | — | US | disclosed |