Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13804925 | 0.76 | MAPT (0.33) | MAPTHTT | |
| SCHEMBL5162076 | 0.72 | MAPT (0.38) | MAPTHTTALDH1A1 | |
| SCHEMBL13804921 | 0.70 | PLK1 (0.60) | MAPTHTTALDH1A1 | |
| SCHEMBL692975 | 0.66 | MAPK1 (0.43) | MAPTHTTALDH1A1 | |
| SCHEMBL13804924 | 0.66 | MAPT (0.36) | MAPTHTTALDH1A1 | |
| SCHEMBL13804685 | 0.64 | MAPT (0.33) | MAPTHTTALDH1A1 | |
| SCHEMBL3861670 | 0.64 | — | — | |
| SCHEMBL6801869 | 0.64 | CYP1A2 (0.55) | MAPTALDH1A1 | |
| SCHEMBL4439651 | 0.63 | — | — | |
| SCHEMBL2852145 | 0.62 | NOTUM (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009068322-A1 | SELECTIVE INHIBITION OF POLO-LIKE KINASE 1 | MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENS CHAFTEN E.V. (DE) | 2009-06-04 | — | — | WO | disclosed |
| EP-2065039-A1 | Selective inhibition of Polo-like kinase 1 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2009-06-03 | — | — | EP | disclosed |