Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | SETD7 | Q8WTS6 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5162076 | 0.77 | MAPT (0.38) | MAPTMEN1ALDH1A1HPGDALOX12 | |
| SCHEMBL13804924 | 0.74 | MAPT (0.36) | MAPTMEN1ALDH1A1HPGDALOX12 | |
| SCHEMBL13804921 | 0.67 | PLK1 (0.60) | MAPTSMN1; SMN2RAB9AMEN1ALDH1A1 | |
| SCHEMBL13804925 | 0.65 | MAPT (0.33) | MAPTHTT | |
| SCHEMBL13804682 | 0.64 | MAPT (0.37) | MAPTALDH1A1HTT | |
| SCHEMBL13804688 | 0.64 | PLK1 (0.57) | MAPTSMN1; SMN2RAB9AMEN1ALDH1A1 | |
| SCHEMBL5160510 | 0.64 | MAPT (0.38) | MAPTSMN1; SMN2RAB9AMEN1ALDH1A1 | |
| SCHEMBL5799546 | 0.60 | MEN1 (0.34) | MAPTMEN1ALDH1A1HPGDALOX12 | |
| SCHEMBL5161482 | 0.58 | MAPT (0.57) | MAPTSMN1; SMN2RAB9AMEN1ALDH1A1 | |
| SCHEMBL5161352 | 0.57 | ALOX5 (0.39) | MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009068322-A1 | SELECTIVE INHIBITION OF POLO-LIKE KINASE 1 | MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENS CHAFTEN E.V. (DE) | 2009-06-04 | — | — | WO | disclosed |
| EP-2065039-A1 | Selective inhibition of Polo-like kinase 1 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2009-06-03 | — | — | EP | disclosed |