Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 8/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.38 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.38 |
| ▸ | TGM2 | P21980 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | BRD2 | P25440 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1771061 | 0.83 | BRD4 (1.00) | BRD4MEN1KMT2ACREBBPBRD2 | |
| SCHEMBL12788173 | 0.81 | AHR (0.51) | BRD4CREBBPAKR1B1CMA1AHR | |
| SCHEMBL13908008 | 0.81 | BRD4 (0.54) | BRD4MEN1KMT2AAKR1B1CMA1 | |
| SCHEMBL12788177 | 0.78 | DRD1 (0.54) | BRD4PKM | |
| SCHEMBL2606232 | 0.76 | BRD4 (0.68) | BRD4MEN1KMT2ACREBBPAHR | |
| SCHEMBL13884894 | 0.75 | BRD4 (0.48) | BRD4MEN1KMT2ACMA1AHR | |
| SCHEMBL7214466 | 0.74 | BRD4 (0.52) | BRD4MEN1KMT2ACMA1AHR | |
| SCHEMBL99208 | 0.74 | MAOA (0.56) | BRD4CMA1AHRTDP2 | |
| SCHEMBL172065 | 0.73 | GRM5 (0.56) | BRD4MEN1KMT2ASRD5A1TDP2 | |
| SCHEMBL4123040 | 0.73 | BRD4 (0.76) | BRD4MEN1KMT2ACREBBPAKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2065382-A1 | CGRP antagonists | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2009-06-03 | — | — | EP | disclosed |