Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | MAP3K12 | Q12852 | 10/20 | 0.35 |
| ▸ | BTK | Q06187 | 2/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3779367 | 0.90 | CCR2 (0.41) | CCR2MAP3K12BTKSYKPIM1 | |
| SCHEMBL3786379 | 0.74 | CCR2 (0.42) | CCR2MAP3K12BTK | |
| SCHEMBL13018958 | 0.72 | SYK (0.42) | CCR2MAP3K12BTKSYKTACR1 | |
| SCHEMBL3788239 | 0.68 | MAP3K12 (0.47) | MAP3K12SYKTACR1 | |
| SCHEMBL1119338 | 0.66 | CCR2 (0.47) | CCR2KCNH2 | |
| SCHEMBL13063398 | 0.66 | MAP3K12 (0.45) | MAP3K12ADRB1SLC6A4TACR1KCNH2 | |
| SCHEMBL20743055 | 0.66 | MAP3K12 (0.44) | MAP3K12 | |
| SCHEMBL20743116 | 0.64 | JAK2 (0.44) | MAP3K12 | |
| Trifluoroacetic Acid SCHEMBL1119773 | 0.64 | CCR2 (0.45) | CCR2KCNH2 | |
| SCHEMBL7074219 | 0.64 | MAPK1 (0.58) | MAP3K12ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009076404-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS ANTAGONISTS OF THE CHEMOKINE CCR2 RECEPTOR | EPIX DELAWARE, INC. (US) | 2009-06-18 | — | — | WO | disclosed |