Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 13/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1378787 | 0.88 | CCR2 (0.47) | CCR2KCNH2ATMF10 | |
| SCHEMBL1378644 | 0.86 | CCR2 (0.43) | CCR2KCNH2ATMF10HTT | |
| SCHEMBL1380865 | 0.81 | CCR2 (0.54) | CCR2KCNH2 | |
| SCHEMBL1380861 | 0.81 | CCR2 (0.54) | CCR2KCNH2 | |
| SCHEMBL4416100 | 0.75 | F10 (0.45) | ATMF10HTTL3MBTL1 | |
| SCHEMBL4420452 | 0.72 | CCR2 (0.52) | CCR2KCNH2 | |
| SCHEMBL1376604 | 0.71 | CCR2 (0.53) | CCR2KCNH2 | |
| SCHEMBL5319253 | 0.71 | CCR2 (0.50) | CCR2KCNH2 | |
| SCHEMBL4425771 | 0.70 | CCR2 (0.62) | CCR2KCNH2 | |
| SCHEMBL1378358 | 0.70 | CCR2 (0.67) | CCR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4740151-B2 | — | — | 2011-08-03 | — | — | JP | claimed |
| EP-1696919-A4 | 3-CYCLOALKYLAMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE CORP (US) | 2009-07-01 | — | — | EP | claimed |
| EP-1696919-A2 | 3-CYCLOALKYLAMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | Incyte Corporation (US) | 2006-09-06 | — | — | EP | claimed |
| WO-2005060665-A2 | 3-CYCLOALKYLAMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE CORPORATION (US) | 2005-07-07 | — | — | WO | claimed |