SCHEMBL1380951

SCHEMBL1380951

CN(C)c1cccc(CC(c2ccc(F)cc2)(c2cccnc2)c2cccnc2)n1

nearest known ligand 0.38

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 6/20 0.36
GPR55 Q9Y2T6 1/20 0.36
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
HIF1A Q16665 1/20 0.35
KCNA5 P22460 2/20 0.34
PTGER2 P43116 1/20 0.34
RORC P51449 2/20 0.33
ADORA2A P29274 1/20 0.33
ADORA2B P29275 1/20 0.33
ADORA1 P30542 1/20 0.33
AOC3 Q16853 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3809308 0.81 CYP19A1 (0.38) CYP19A1GPR55CYP1A2CYP3A4CYP2C9
SCHEMBL1377502 0.81 KCNH3 (0.39) CYP19A1GPR55CYP1A2CYP3A4CYP2C9
SCHEMBL1381538 0.77 GRM2 (0.39) CYP19A1CYP3A4
SCHEMBL3810171 0.77 CYP1A2 (0.41) GPR55CYP1A2PTGER2ADORA2AADORA2B
SCHEMBL1378598 0.77 KCNA5 (0.51) GPR55CYP1A2CYP3A4KCNA5PTGER2
SCHEMBL1378413 0.76 CYP3A4 (0.54) CYP19A1GPR55CYP1A2CYP3A4CYP2C9
SCHEMBL1377359 0.74 NR3C2 (0.40) CYP19A1GPR55PTGER2
SCHEMBL1378197 0.72 CYP1A2 (0.42) CYP19A1GPR55CYP1A2CYP3A4CYP2C9
SCHEMBL1379275 0.71 PTGER2 (0.38) GPR55PTGER2
SCHEMBL3811774 0.71 KCNA5 (0.45) GPR55CYP1A2CYP3A4KCNA5PTGER2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4719744-B2 2011-07-06 JP claimed
EP-1776355-A4 POTASSIUM CHANNEL INHIBITORS MERCK & CO INC (US) 2009-08-12 EP claimed
EP-1776355-A2 POTASSIUM CHANNEL INHIBITORS Merck & Co., Inc. (US) 2007-04-25 EP claimed
WO-2006014877-A2 POTASSIUM CHANNEL INHIBITORS MERCK & CO., INC. (US) 2006-02-09 WO claimed
EP-1776355-A4 POTASSIUM CHANNEL INHIBITORS MERCK & CO INC (US) 2009-08-12 EP disclosed
EP-1776355-A2 POTASSIUM CHANNEL INHIBITORS Merck & Co., Inc. (US) 2007-04-25 EP disclosed
WO-2006014877-A2 POTASSIUM CHANNEL INHIBITORS MERCK & CO., INC. (US) 2006-02-09 WO disclosed