SCHEMBL1378413

SCHEMBL1378413

Fc1ccc(C(Cc2cccnc2)(c2cccnc2)c2cccnc2)cc1

nearest known ligand 0.55

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.54
CYP1A2 P05177 1/20 0.54
CYP2C9 P11712 1/20 0.54
CYP2C19 P33261 1/20 0.54
HIF1A Q16665 1/20 0.54
KCNA5 P22460 1/20 0.46
FDPS P14324 4/20 0.44
CYP19A1 P11511 4/20 0.43
GAA P10253 1/20 0.43
BTN3A1 O00481 1/20 0.42
PDE3A Q14432 1/20 0.42
POLB P06746 1/20 0.42
GPR55 Q9Y2T6 1/20 0.40
CYP2D6 P10635 1/20 0.40
SLC6A2 P23975 1/20 0.40
SLC6A4 P31645 1/20 0.40
SLC6A3 Q01959 1/20 0.40
KCNH2 Q12809 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1378197 0.88 CYP1A2 (0.42) CYP3A4CYP1A2CYP2C9CYP2C19HIF1A
SCHEMBL3819228 0.86 CYP1A2 (0.40) CYP3A4CYP1A2CYP2C9CYP2C19HIF1A
SCHEMBL10461563 0.83 CYP3A4 (0.73) CYP3A4CYP1A2CYP2C9CYP2C19HIF1A
SCHEMBL4200425 0.81 CYP19A1 (0.47) CYP3A4CYP1A2CYP2C9CYP2C19HIF1A
SCHEMBL1379315 0.80 GPR55 (0.44) CYP3A4CYP1A2CYP2C9CYP2C19HIF1A
SCHEMBL3810301 0.78 GPR55 (0.45) CYP3A4CYP1A2CYP2C9CYP2C19GAA
SCHEMBL1380983 0.78 GPR55 (0.45) CYP3A4CYP1A2CYP2C9CYP2C19HIF1A
SCHEMBL1377502 0.76 KCNH3 (0.39) CYP3A4CYP1A2CYP2C9CYP2C19HIF1A
SCHEMBL3809308 0.76 CYP19A1 (0.38) CYP3A4CYP1A2CYP2C9CYP2C19HIF1A
SCHEMBL1380951 0.76 CYP19A1 (0.36) CYP3A4CYP1A2CYP2C9CYP2C19HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4719744-B2 2011-07-06 JP claimed
EP-1776355-A4 POTASSIUM CHANNEL INHIBITORS MERCK & CO INC (US) 2009-08-12 EP claimed
EP-1776355-A2 POTASSIUM CHANNEL INHIBITORS Merck & Co., Inc. (US) 2007-04-25 EP claimed
WO-2006014877-A2 POTASSIUM CHANNEL INHIBITORS MERCK & CO., INC. (US) 2006-02-09 WO claimed
EP-1776355-A4 POTASSIUM CHANNEL INHIBITORS MERCK & CO INC (US) 2009-08-12 EP disclosed
EP-1776355-A2 POTASSIUM CHANNEL INHIBITORS Merck & Co., Inc. (US) 2007-04-25 EP disclosed
WO-2006014877-A2 POTASSIUM CHANNEL INHIBITORS MERCK & CO., INC. (US) 2006-02-09 WO disclosed