Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.59 |
| ▸ | ACHE | P22303 | 2/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL61542 | 0.93 | HDAC1 (0.52) | HDAC1HDAC6ACHEDRD4AKR1B1 | |
| SCHEMBL61089 | 0.92 | HDAC1 (0.53) | HDAC1HDAC6ACHEDRD4AKR1B1 | |
| SCHEMBL61054 | 0.81 | L3MBTL1 (0.49) | KMT2AALDH1A1KDM4EMEN1HPGD | |
| SCHEMBL3806595 | 0.81 | HDAC1 (0.57) | HDAC1HDAC6ACHEDRD4AKR1B1 | |
| SCHEMBL13809376 | 0.81 | TRPV1 (0.45) | KMT2AALDH1A1KDM4EMEN1NPSR1 | |
| SCHEMBL61090 | 0.81 | HDAC1 (0.58) | HDAC1HDAC6ACHEDRD4AKR1B1 | |
| SCHEMBL62750 | 0.80 | HDAC1 (0.60) | HDAC1HDAC6ACHEDRD4AKR1B1 | |
| SCHEMBL16939031 | 0.80 | POLB (0.43) | KMT2AALDH1A1KDM4EMEN1NPSR1 | |
| SCHEMBL62007 | 0.80 | BRD3 (0.46) | HDAC1HDAC6KMT2AALDH1A1GAA | |
| SCHEMBL62772 | 0.80 | HDAC4 (0.45) | KMT2AALDH1A1KDM4EMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009076631-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-06-18 | — | — | WO | disclosed |