Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | CASP1 | P29466 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL61054 | 0.89 | L3MBTL1 (0.49) | MAPTMAPK1POLBNPSR1GAA | |
| SCHEMBL12264857 | 0.86 | ROCK2 (0.52) | TRPV1MAPK1GAAKMT2ATAAR1 | |
| SCHEMBL13809575 | 0.81 | HDAC1 (0.59) | MAPK1POLBNPSR1GAAMEN1 | |
| SCHEMBL61542 | 0.80 | HDAC1 (0.52) | POLBGAALMNAPARP1 | |
| SCHEMBL61089 | 0.79 | HDAC1 (0.53) | POLBGAAMEN1KMT2A | |
| SCHEMBL62007 | 0.79 | BRD3 (0.46) | MAPTPOLBGAAKMT2AL3MBTL1 | |
| SCHEMBL16939031 | 0.79 | POLB (0.43) | MAPTMAPK1POLBNPSR1GAA | |
| SCHEMBL62772 | 0.79 | HDAC4 (0.45) | POLBGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL3312381 | 0.77 | LMNA (0.57) | MAPTMAPK1POLBGAAKMT2A | |
| SCHEMBL62381 | 0.76 | ROCK2 (0.51) | MAPK1KMT2AATMLMNAPABPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009076631-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-06-18 | — | — | WO | disclosed |