Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | F13A1 | P00488 | 1/20 | 0.31 |
| ▸ | TGM2 | P21980 | 1/20 | 0.31 |
| ▸ | TGM1 | P22735 | 1/20 | 0.31 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.30 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13809768 | 0.87 | NPC1 (0.40) | HSD11B1NPC1RAB9ASMN1; SMN2CNR2 | |
| SCHEMBL13809991 | 0.86 | EPHX2 (0.37) | HSD11B1NPC1RAB9ASMN1; SMN2EPHX2 | |
| SCHEMBL13810083 | 0.85 | NPC1 (0.37) | HSD11B1NPC1RAB9ASMN1; SMN2CNR2 | |
| SCHEMBL13810072 | 0.84 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2EPHX2F13A1 | |
| SCHEMBL13810082 | 0.83 | NPC1 (0.38) | HSD11B1NPC1RAB9ASMN1; SMN2CNR2 | |
| SCHEMBL13810030 | 0.83 | EPHX2 (0.40) | HSD11B1NPC1RAB9ASMN1; SMN2EPHX2 | |
| SCHEMBL13809780 | 0.83 | POLB (0.38) | HSD11B1NPC1RAB9ASMN1; SMN2EPHX2 | |
| SCHEMBL13809787 | 0.83 | NPC1 (0.36) | HSD11B1NPC1RAB9ASMN1; SMN2CNR2 | |
| SCHEMBL13810079 | 0.83 | NPC1 (0.36) | HSD11B1NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL13809989 | 0.82 | NPC1 (0.37) | HSD11B1NPC1RAB9ASMN1; SMN2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009074789-A1 | AMIDO-THIOPHENE COMPOUNDS AND THEIR USE AS 11-BETA-HSD1 INHIBITORS | THE UNIVERSITY OF EDINBURGH (GB) | 2009-06-18 | — | — | WO | disclosed |