Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | F12 | P00748 | 1/20 | 0.30 |
| ▸ | F13A1 | P00488 | 1/20 | 0.30 |
| ▸ | TGM2 | P21980 | 1/20 | 0.30 |
| ▸ | TGM1 | P22735 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13809991 | 0.87 | EPHX2 (0.37) | EPHX2HSD11B1MMP13CNR2POLB | |
| SCHEMBL13810098 | 0.83 | HSD11B1 (0.36) | EPHX2HSD11B1CNR2POLBTDP1 | |
| SCHEMBL13809768 | 0.81 | NPC1 (0.40) | HSD11B1CNR2POLBTDP1NPC1 | |
| SCHEMBL13809966 | 0.81 | CNR2 (0.34) | HSD11B1CNR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13809780 | 0.80 | POLB (0.38) | EPHX2HSD11B1CNR2POLBTDP1 | |
| SCHEMBL13809786 | 0.80 | PDE4B (0.38) | HSD11B1MMP13POLBTDP1NPC1 | |
| SCHEMBL13810072 | 0.79 | NPC1 (0.45) | EPHX2NPC1RAB9ASMN1; SMN2F13A1 | |
| SCHEMBL13809985 | 0.78 | LMNA (0.34) | HSD11B1CNR2POLBTDP1NPC1 | |
| SCHEMBL13810082 | 0.78 | NPC1 (0.38) | HSD11B1CNR2POLBTDP1NPC1 | |
| SCHEMBL13809974 | 0.78 | SLC18A3 (0.36) | HSD11B1POLBTDP1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009074789-A1 | AMIDO-THIOPHENE COMPOUNDS AND THEIR USE AS 11-BETA-HSD1 INHIBITORS | THE UNIVERSITY OF EDINBURGH (GB) | 2009-06-18 | — | — | WO | disclosed |