Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | F13A1 | P00488 | 1/20 | 0.40 |
| ▸ | TGM2 | P21980 | 1/20 | 0.40 |
| ▸ | TGM1 | P22735 | 1/20 | 0.40 |
| ▸ | USP5 | P45974 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13810098 | 0.84 | HSD11B1 (0.36) | NPC1EPHX2SMN1; SMN2RAB9AF13A1 | |
| SCHEMBL13810349 | 0.82 | HSD11B1 (0.43) | NPC1EPHX2SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL13809768 | 0.82 | NPC1 (0.40) | NPC1SMN1; SMN2RAB9AF13A1TGM2 | |
| SCHEMBL13809991 | 0.81 | EPHX2 (0.37) | NPC1EPHX2SMN1; SMN2RAB9ALMNA | |
| SCHEMBL3917592 | 0.80 | NPC1 (0.64) | NPC1EPHX2SMN1; SMN2RAB9AHTT | |
| SCHEMBL13810082 | 0.79 | NPC1 (0.38) | NPC1SMN1; SMN2RAB9A | |
| SCHEMBL13810030 | 0.79 | EPHX2 (0.40) | NPC1EPHX2SMN1; SMN2RAB9AF13A1 | |
| SCHEMBL13810079 | 0.78 | NPC1 (0.36) | NPC1SMN1; SMN2RAB9A | |
| SCHEMBL13809780 | 0.78 | POLB (0.38) | NPC1EPHX2SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL13809787 | 0.78 | NPC1 (0.36) | NPC1SMN1; SMN2RAB9AF13A1TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009074789-A1 | AMIDO-THIOPHENE COMPOUNDS AND THEIR USE AS 11-BETA-HSD1 INHIBITORS | THE UNIVERSITY OF EDINBURGH (GB) | 2009-06-18 | — | — | WO | disclosed |