Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.57 |
| ▸ | GSK3B | P49841 | 8/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.55 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.55 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.55 |
| ▸ | GSK3A | P49840 | 2/20 | 0.53 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2671627 | 0.88 | AAK1 (0.52) | AAK1HDAC6GSK3BFGFR1FGFR2 | |
| SCHEMBL12907471 | 0.81 | AAK1 (0.57) | AAK1HDAC6GSK3BFGFR1FGFR2 | |
| SCHEMBL2671672 | 0.80 | MAPK1 (0.50) | AAK1GSK3BGSK3AMAP2K4MAPK1 | |
| SCHEMBL12907256 | 0.80 | JAK2 (0.69) | AAK1MAP2K4MAPK1MAPK6 | |
| SCHEMBL12294028 | 0.79 | CHEK1 (0.58) | AAK1HDAC6GSK3BFGFR1FGFR2 | |
| SCHEMBL2671796 | 0.77 | MAP2K4 (0.53) | HDAC6MAP2K4 | |
| SCHEMBL4407779 | 0.76 | GSK3B (0.47) | AAK1HDAC6GSK3B | |
| SCHEMBL4150213 | 0.76 | DYRK1A (0.45) | AAK1HDAC6GSK3B | |
| SCHEMBL4487525 | 0.75 | GSK3B (0.73) | AAK1HDAC6GSK3BFGFR1FGFR2 | |
| SCHEMBL27909188 | 0.73 | GSK3B (0.54) | GSK3BMAP2K4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765788-B1 | 3-AMINOINDAZOLE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SGK-ASSOCIATED DISEASES | MERCK PATENT GMBH (DE) | 2009-06-03 | — | — | EP | disclosed |