Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.57 |
| ▸ | MAP2K4 | P45985 | 6/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.56 |
| ▸ | MAPK6 | Q16659 | 4/20 | 0.56 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.56 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.53 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.53 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.53 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.50 |
| ▸ | BCR | P11274 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | RXRA | P19793 | 1/20 | 0.47 |
| ▸ | RXRB | P28702 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31746650 | 0.87 | DYRK1A (0.52) | AAK1MAP2K4MAPK1MAPK6MAPKAPK3 | |
| SCHEMBL1144879 | 0.87 | DYRK1A (0.52) | AAK1MAP2K4MAPK1MAPK6MAPKAPK3 | |
| SCHEMBL12907256 | 0.83 | JAK2 (0.69) | AAK1MAP2K4MAPK1MAPK6MAPKAPK5 | |
| SCHEMBL12907457 | 0.82 | JAK2 (0.67) | MAP2K4GSK3BFGFR1FGFR2FGFR3 | |
| SCHEMBL13810906 | 0.81 | AAK1 (0.67) | AAK1MAP2K4MAPK1MAPK6HDAC6 | |
| SCHEMBL22926087 | 0.81 | HPGD (0.51) | ABL1BCRGSK3B | |
| SCHEMBL12907451 | 0.81 | FGFR1 (0.70) | AAK1MAP2K4MAPK1MAPK6MAPKAPK3 | |
| SCHEMBL14397096 | 0.80 | PDPK1 (0.53) | MAP2K4MAPK1MAPK6MAPKAPK3MAPKAPK5 | |
| SCHEMBL31504557 | 0.78 | MAP2K4 (0.57) | MAP2K4MAPK1MAPK6MAPKAPK3MAPKAPK5 | |
| SCHEMBL1145076 | 0.78 | MAP2K4 (0.57) | MAP2K4MAPK1MAPK6MAPKAPK3MAPKAPK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872039-B2 | N-3-chlorobenzyl-3-amino-1H-indazole-5-carboxamide; 3-aminoindazoles; glucocorticoid-depedent kinase (SGK) inhibitors; SGK-induced diseases; diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and renal diseases, fibrosis; inflammatory agents | MERCK PATENT GESELLSCHAFT (DE) | 2011-01-18 | — | — | US | disclosed |