SCHEMBL138121

SCHEMBL138121

O=C(O)Cc1c[nH]c2ccc(O)cc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 6/20 1.00
TSHR P16473 4/20 1.00
ALDH1A1 P00352 4/20 1.00
LMNA P02545 3/20 1.00
NFKB1 P19838 3/20 1.00
CYP2C9 P11712 3/20 1.00
PMP22 Q01453 2/20 1.00
HPGD P15428 2/20 1.00
GLA P06280 1/20 1.00
NR4A1 P22736 1/20 0.72
KDM4E B2RXH2 5/20 0.64
HTR2C P28335 7/20 0.62
HTR1A P08908 5/20 0.62
HTR2A P28223 5/20 0.62
HTR2B P41595 4/20 0.62
CYP3A4 P08684 3/20 0.62
MAPT P10636 3/20 0.62
BLM P54132 3/20 0.62
HTR7 P34969 2/20 0.62
SLC6A4 P31645 2/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29350604 1.00 NPSR1 (1.00) NPSR1TSHRALDH1A1LMNANFKB1
SCHEMBL6663269 0.87 ALDH1A1 (0.77) NPSR1TSHRALDH1A1LMNANFKB1
SCHEMBL29440828 0.85 NPSR1 (0.74) NPSR1TSHRALDH1A1LMNANFKB1
SCHEMBL1032415 0.85 NPSR1 (0.74) NPSR1TSHRALDH1A1LMNANFKB1
SCHEMBL14790896 0.85 NPSR1 (0.74) NPSR1TSHRALDH1A1LMNANFKB1
SCHEMBL1723364 0.84 NPSR1 (0.72) NPSR1TSHRALDH1A1LMNANFKB1
SCHEMBL20182375 0.83 NPSR1 (0.70) NPSR1TSHRALDH1A1LMNANFKB1
Serotonin SCHEMBL7805171 0.83 NPSR1 (0.68) NPSR1TSHRALDH1A1LMNANFKB1
SCHEMBL1615011 0.82 TSHR (0.69) NPSR1TSHRALDH1A1LMNANFKB1
SCHEMBL6116786 0.82 TSHR (0.69) NPSR1TSHRALDH1A1LMNANFKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 5874 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4747627-A1 METHODS AND SYSTEMS FOR PREDICTIVE CLASSIFICATION BY MASS SPECTROMETRY AND TRAINED LARGE SPECTRAL MODELS Matterworks Inc (US) 2026-05-27 EP claimed
CN-122084713-A Microelectrode, probe and electrochemical detection device 2026-05-26 CN claimed
US-20260091037-A1 METHODS FOR INCREASING SEPIAPTERIN PLASMA EXPOSURE PTC THERAPEUTICS MP INC (US) 2026-04-02 US claimed
EP-3801534-B1 TREATMENT OF PHENYLKETONURIA WITH SEPIAPTERIN PTC THERAPEUTICS MP INC (US) 2026-02-18 EP claimed
US-12486279-B2 Indole alkaloid with fungicidal effect AZUL NATURAL S.A. DE C.V. (MX) 2025-12-02 US claimed
US-20250228842-A1 USES OF A SOMATOSTATIN MODULATOR FOR THE TREATMENT OF CARCINOID SYNDROME Crinetics Pharmaceuticals, Inc. 2025-07-17 US claimed
US-20250205310-A1 METHOD FOR REVERSING BODY-WIDE AGE-ASSOCIATED FUNCTIONAL CHANGES THE CHINESE UNIVERSITY OF HONG KONG (CN) 2025-06-26 US claimed
US-20250195529-A1 COMPOSITIONS AND METHODS FOR INCREASING TETRAHYDROBIOPTERIN PLASMA EXPOSURE PTC THERAPEUTICS MP, INC. 2025-06-19 US claimed
CN-120064627-A Biomarker for diagnosing parkinsonism accompanied with rapid eye movement and sleep behavior disorder and application thereof 上海健康医学院 2025-05-30 CN claimed
EP-4551232-A1 METABOLOMIC IMPROVEMENTS USING RESISTANT STARCH SUPPLEMENTATION Mcpharma Biotech Inc. (CA) 2025-05-14 EP claimed
EP-0415802-B1 KERATINOUS FIBRES DYEING PROCESS WITH MONOHYDROXYINDOLE AND HYDROXYINDOLE-5,6-DISUBSTITUTED AND COMPOSITION L'OREAL (FR) 1993-03-10 EP claimed
EP-0271186-B1 HYDROXYINDOLES AND THEIR USE IN DYEING REPLIGEN CORPORATION (US) 1992-12-30 EP claimed
US-5135544-A Applying indole mixture, rinsing, applying periodate solution L'OREAL (FR) 1992-08-04 US claimed
EP-0452765-A2 Pharmaceutical composition and medical uses of dioxopiperidine derivatives, especially as immune response potentiators, antiviral and antibacterial agents BTG INTERNATIONAL LIMITED (GB) 1991-10-23 EP claimed
US-4918084-A ANXIOLYTIC AGENTS; BENZODIAZEPINE INVERSE AGONIST ANTAGONISTS NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) 1990-04-17 US claimed
EP-0271186-A1 Hydroxyindoles and their use in dyeing REPLIGEN CORPORATION (US) 1988-06-15 EP claimed
EP-0252404-A2 5-Hydroxy-3-indoleacetic acid fluorescence polarization immunoassay ABBOTT LABORATORIES (US) 1988-01-13 EP claimed
EP-0216555-A2 Use of dioxopiperidine derivatives in the treatment of anxiety, for the reduction of chronic abnormally high brain levels of serotonin or 5-hydroxy-indoleacetic acid, and in the treatment of bacterial or viral infections BTG INTERNATIONAL LIMITED (GB) 1987-04-01 EP claimed
US-4042329-A Method and device for detecting cholesterol BECTON, DICKINSON AND COMPANY (US) 1977-08-16 US claimed
US-3964871-A GLUCOSE OXIDASE, HORSERADISH PEROXIDASE BECTON, DICKINSON AND COMPANY (US) 1976-06-22 US claimed