SCHEMBL20182375

SCHEMBL20182375

O=C(Cc1c[nH]c2ccc(O)cc12)NI

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 5/20 0.70
ALDH1A1 P00352 4/20 0.70
LMNA P02545 3/20 0.70
TSHR P16473 3/20 0.70
CYP2C9 P11712 3/20 0.70
NFKB1 P19838 3/20 0.70
HPGD P15428 2/20 0.70
PMP22 Q01453 2/20 0.70
GLA P06280 1/20 0.70
NR4A1 P22736 1/20 0.67
KDM4E B2RXH2 4/20 0.57
CYP2D6 P10635 4/20 0.57
SPR P35270 4/20 0.57
CYP3A4 P08684 3/20 0.57
MAPT P10636 3/20 0.57
CYP1A2 P05177 3/20 0.57
BLM P54132 2/20 0.57
IDO1 P14902 1/20 0.57
NOTUM Q6P988 1/20 0.57
HTR2C P28335 7/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20182374 0.87 NPSR1 (0.68) NPSR1ALDH1A1LMNATSHRCYP2C9
SCHEMBL29350604 0.83 NPSR1 (1.00) NPSR1ALDH1A1LMNATSHRCYP2C9
SCHEMBL138121 0.83 NPSR1 (1.00) NPSR1ALDH1A1LMNATSHRCYP2C9
SCHEMBL7657570 0.82 NPSR1 (0.62) NPSR1ALDH1A1LMNATSHRCYP2C9
SCHEMBL1032415 0.81 NPSR1 (0.74) NPSR1ALDH1A1LMNATSHRCYP2C9
SCHEMBL14790896 0.81 NPSR1 (0.74) NPSR1ALDH1A1LMNATSHRCYP2C9
SCHEMBL7023934 0.81 LMNA (0.64) NPSR1ALDH1A1LMNATSHRCYP2C9
SCHEMBL853729 0.81 NPSR1 (0.68) NPSR1ALDH1A1LMNATSHRCYP2C9
SCHEMBL20182258 0.80 ALDH1A1 (0.59) NPSR1ALDH1A1LMNATSHRCYP2C9
SCHEMBL20182261 0.80 NPSR1 (0.63) NPSR1ALDH1A1LMNATSHRCYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018094005-A1 MYELOPEROXIDASE IMAGING AGENTS THE GENERAL HOSPITAL CORPORATION (US) 2018-05-24 WO disclosed