Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13812675 | 0.89 | NR1H4 (0.48) | SIRT2MAPTNR1H4MEN1NPC1 | |
| SCHEMBL13812550 | 0.87 | SIRT2 (0.52) | SIRT2MAPTNR1H4MEN1NPC1 | |
| SCHEMBL13812553 | 0.85 | SIRT2 (0.51) | SIRT2MAPTNR1H4NPC1RAB9A | |
| SCHEMBL13812549 | 0.85 | SIRT2 (0.58) | SIRT2NR1H4RXFP1 | |
| SCHEMBL3863657 | 0.83 | P2RX1 (0.62) | SIRT2NR1H4MEN1NPC1RAB9A | |
| SCHEMBL13812548 | 0.82 | NR1H4 (0.52) | SIRT2MAPTNR1H4MEN1NPC1 | |
| SCHEMBL13812584 | 0.81 | MEN1 (0.53) | SIRT2MAPTNR1H4MEN1NPC1 | |
| SCHEMBL13812764 | 0.80 | LRRK2 (0.55) | SIRT2MAPTNR1H4MEN1KMT2A | |
| SCHEMBL13812799 | 0.78 | NR1H4 (0.50) | SIRT2MAPTNR1H4MEN1NPC1 | |
| SCHEMBL13812642 | 0.78 | P2RX1 (0.61) | SIRT2MAPTNR1H4MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |