Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | GRM5 | P41594 | 1/20 | 0.53 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.52 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.52 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | PNLIP | P16233 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13812763 | 0.90 | GRM5 (0.53) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL3863657 | 0.86 | P2RX1 (0.62) | MEN1KMT2ASIRT2NR1H4 | |
| SCHEMBL13812736 | 0.85 | KCNK3 (0.56) | LRRK2MEN1KMT2AKDM4ESIRT2 | |
| SCHEMBL13812584 | 0.85 | MEN1 (0.53) | LRRK2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL13812577 | 0.84 | P2RX1 (0.55) | MAPTSIRT2KCNMA1 | |
| SCHEMBL13812550 | 0.83 | SIRT2 (0.52) | MAPTMEN1KMT2ASIRT2NR1H4 | |
| SCHEMBL24438365 | 0.82 | ALDH1A1 (0.69) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL30692666 | 0.82 | ALDH1A1 (0.69) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL13812799 | 0.82 | NR1H4 (0.50) | ALDH1A1MAPTMEN1KMT2AHPGD | |
| SCHEMBL13812606 | 0.82 | P2RX1 (0.59) | MAPTSIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |