Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 15/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.38 |
| ▸ | LCAT | P04180 | 2/20 | 0.33 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.33 |
| ▸ | ITGAL | P20701 | 2/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4331493 | 0.80 | CCR2 (0.75) | CCR2KCNH2 | |
| SCHEMBL1381009 | 0.76 | CCR2 (0.67) | CCR2KCNH2 | |
| SCHEMBL4563545 | 0.75 | CCR2 (0.52) | CCR2KCNH2LCAT | |
| SCHEMBL4562632 | 0.73 | CCR2 (0.67) | CCR2KCNH2LCAT | |
| SCHEMBL4426357 | 0.72 | CCR2 (0.53) | CCR2KCNH2LCAT | |
| SCHEMBL4422389 | 0.72 | CCR2 (0.65) | CCR2KCNH2 | |
| SCHEMBL4415932 | 0.72 | CCR2 (0.52) | CCR2KCNH2LCAT | |
| SCHEMBL1378358 | 0.72 | CCR2 (0.67) | CCR2KCNH2 | |
| SCHEMBL1377717 | 0.71 | CCR2 (0.52) | CCR2KCNH2LCAT | |
| SCHEMBL4420729 | 0.71 | CCR2 (0.65) | CCR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4740151-B2 | — | — | 2011-08-03 | — | — | JP | claimed |
| EP-1696919-A4 | 3-CYCLOALKYLAMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE CORP (US) | 2009-07-01 | — | — | EP | claimed |
| EP-1696919-A2 | 3-CYCLOALKYLAMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | Incyte Corporation (US) | 2006-09-06 | — | — | EP | claimed |
| WO-2005060665-A2 | 3-CYCLOALKYLAMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE CORPORATION (US) | 2005-07-07 | — | — | WO | claimed |