Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 20/20 | 0.77 |
| ▸ | ICAM1 | P05362 | 20/20 | 0.77 |
| ▸ | ITGAL | P20701 | 20/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14566279 | 0.90 | ITGB2 (0.62) | ITGB2ICAM1ITGAL | |
| SCHEMBL4242841 | 0.87 | ITGB2 (1.00) | ITGB2ICAM1ITGAL | |
| SCHEMBL13817194 | 0.87 | ITGB2 (0.84) | ITGB2ICAM1ITGAL | |
| SCHEMBL4242837 | 0.87 | ITGB2 (1.00) | ITGB2ICAM1ITGAL | |
| SCHEMBL13817022 | 0.87 | ITGB2 (0.65) | ITGB2ICAM1ITGAL | |
| SCHEMBL13817008 | 0.86 | ITGB2 (1.00) | ITGB2ICAM1ITGAL | |
| SCHEMBL2394410 | 0.85 | ITGB2 (1.00) | ITGB2ICAM1ITGAL | |
| SCHEMBL2394405 | 0.85 | ITGB2 (1.00) | ITGB2ICAM1ITGAL | |
| SCHEMBL13817172 | 0.84 | ITGB2 (0.77) | ITGB2ICAM1ITGAL | |
| SCHEMBL13817004 | 0.84 | ITGB2 (0.77) | ITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7550494-B2 | Small molecules useful in the treatment of inflammatory disease | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-7550494-B2 | Small molecules useful in the treatment of inflammatory disease | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-7462637-B2 | Derivatives of [6,7-dihydro-5H-imidazo[1,2--a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-12-09 | — | — | US | disclosed |
| US-7462637-B2 | Derivatives of [6,7-dihydro-5H-imidazo[1,2--a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-12-09 | — | — | US | disclosed |
| EP-1216247-B1 | IMIDAZOIMIDAZOLES AND TRIAZOLES AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMA (US) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007084882-A2 | PROCESS FOR THE PREPARATION OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-A]IMIDAZOLE-3-SULFONIC ACID AMIDES AND INTERMEDIATES USED THEREIN | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-07-26 | — | — | WO | disclosed |