Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 20/20 | 1.00 |
| ▸ | ICAM1 | P05362 | 20/20 | 1.00 |
| ▸ | ITGAL | P20701 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2394405 | 1.00 | ITGB2 (1.00) | ITGB2ICAM1ITGAL | |
| SCHEMBL4242841 | 0.89 | ITGB2 (1.00) | ITGB2ICAM1ITGAL | |
| SCHEMBL13817194 | 0.89 | ITGB2 (0.84) | ITGB2ICAM1ITGAL | |
| SCHEMBL4242837 | 0.89 | ITGB2 (1.00) | ITGB2ICAM1ITGAL | |
| SCHEMBL13817008 | 0.88 | ITGB2 (1.00) | ITGB2ICAM1ITGAL | |
| SCHEMBL13817299 | 0.87 | ITGB2 (0.77) | ITGB2ICAM1ITGAL | |
| SCHEMBL13817023 | 0.87 | ITGB2 (0.76) | ITGB2ICAM1ITGAL | |
| SCHEMBL13817324 | 0.86 | ITGB2 (0.76) | ITGB2ICAM1ITGAL | |
| SCHEMBL4238585 | 0.86 | ITGB2 (0.75) | ITGB2ICAM1ITGAL | |
| SCHEMBL4238582 | 0.86 | ITGB2 (0.75) | ITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8552205-B2 | Derivatives of 6,7-dihydro-5H-imidazo[1,2-alpha]imidazole-3-carboxylic acid amides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-10-08 | — | — | US | disclosed |
| US-20110224188-A1 | DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-alpha]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-09-15 | — | — | US | disclosed |
| EP-2225238-A1 | DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZOÝ1,2- ¨IMIDAZOLE-3- CARBOXYLIC ACID AMIDES | Boehringer Ingelheim International GmbH (DE) | 2010-09-08 | — | — | EP | disclosed |
| US-7550494-B2 | Small molecules useful in the treatment of inflammatory disease | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-7550494-B2 | Small molecules useful in the treatment of inflammatory disease | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |
| WO-2009070485-A1 | DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-α]IMIDAZOLE-3- CARBOXYLIC ACID AMIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-06-04 | — | — | WO | disclosed |
| US-20090088571-A1 | Synthesis of 6,7-Dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-02 | — | — | US | disclosed |
| US-7462637-B2 | Derivatives of [6,7-dihydro-5H-imidazo[1,2--a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-12-09 | — | — | US | disclosed |
| EP-1216247-B1 | IMIDAZOIMIDAZOLES AND TRIAZOLES AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMA (US) | 2008-11-05 | — | — | EP | disclosed |
| EP-1558248-A1 | DERIVATIVES OF [6,7-DIHYDRO-5H-IMIDAZO[1,2-A]IMIDAZOLE-3-SULFONYL]-PYRROLIDINE-2-CARBOXYLIC ACID AMIDE AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2005-08-03 | — | — | EP | disclosed |
| US-20050054704-A1 | Derivatives of [6,7-dihydro-5H- Imidazo[1,2-a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-03-10 | — | — | US | disclosed |
| WO-2004041273-A1 | DERIVATIVES OF [6,7-DIHYDRO-5H-IMIDAZO[1,2-α]IMIDAZOLE-3-SULFONYL]-PYRROLIDINE-2-CARBOXYLIC ACID AMIDE AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2004-05-21 | — | — | WO | disclosed |
| US-6441183-B1 | USEFUL AS AN INTERMEDIATE IN THE PREPARATION OF CERTAIN SMALL MOLECULES THAT ARE USEFUL IN THERAPY OR PROPHYLAXIS OF INFLAMMATORY AND IMMUNE CELL-MEDIATED DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2002-08-27 | — | — | US | disclosed |
| US-6437148-B1 | 2-(ALKOXYCARBONYLMETHYLIMINO),3-(3,5-DICHLOROPHENYL), 5-METHYL-5-(4-BROMOBENZYL)IMIDAZOLIDIN-4-ONE; INTERMEDIATE FOR DRUGS USEFUL IN TREATING INFLAMMATORY AND IMMUNE CELL-MEDIATED DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2002-08-20 | — | — | US | disclosed |
| US-20020087009-A1 | INTERMEDIATES FOR (R)-3(4-BROMOBENZYL)-1-(3,5-DICHLOROPHENYL)-5-IODO-3-METHYL-1-H-IMIDAZO[1,2-A] IMIDAZOL-2-ONE | FRUTOS ROGELIO P (US) | 2002-07-04 | — | — | US | disclosed |
| US-20020082441-A1 | Useful as an intermediate in preparation of certain small molecules that are useful in therapy or prophylaxis of inflammatory and immune cell-mediated diseases | FRUTOS ROGELIO P (US) | 2002-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224188-A1 | DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-alpha]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES | HPGDS, COL14A1, ARG1 | ITGB2 346/4885ICAM1 4/4885ITGAL 74/4885 |
| US-20020087009-A1 | INTERMEDIATES FOR (R)-3(4-BROMOBENZYL)-1-(3,5-DICHLOROPHENYL)-5-IODO-3-METHYL-1-H-IMIDAZO[1,2-A] IMIDAZOL-2-ONE | IRAK1, IRAK3, TLR1 | ITGB2 804/4885ICAM1 10/4885ITGAL 862/4885 |
| US-20050054704-A1 | Derivatives of [6,7-dihydro-5H- Imidazo[1,2-a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide | ARG1, HPGDS, MIF | ITGB2 700/4885ICAM1 4/4885ITGAL 152/4885 |
| US-20090088571-A1 | Synthesis of 6,7-Dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides | ICAM1, CD14, VCAM1 | ITGB2 125/4885ICAM1 1/4885ITGAL 33/4885 |
| US-20020082441-A1 | Useful as an intermediate in preparation of certain small molecules that are useful in therapy or prophylaxis of inflammatory and immune cell-mediated diseases | ICAM1, MYD88, IRAK1 | ITGB2 759/4885ICAM1 1/4885ITGAL 800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.