Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 19/20 | 0.76 |
| ▸ | ICAM1 | P05362 | 19/20 | 0.76 |
| ▸ | ITGAL | P20701 | 19/20 | 0.76 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12802465 | 0.91 | ITGAL (0.64) | ITGB2ICAM1ITGALTMEM97 | |
| SCHEMBL2390822 | 0.91 | ITGAL (0.63) | ITGB2ICAM1ITGALTMEM97 | |
| SCHEMBL27465156 | 0.88 | ITGB2 (0.65) | ITGB2ICAM1ITGALTMEM97 | |
| SCHEMBL27465168 | 0.87 | ITGB2 (0.66) | ITGB2ICAM1ITGALTMEM97 | |
| SCHEMBL2394405 | 0.87 | ITGB2 (1.00) | ITGB2ICAM1ITGAL | |
| SCHEMBL2394410 | 0.87 | ITGB2 (1.00) | ITGB2ICAM1ITGAL | |
| SCHEMBL13817022 | 0.86 | ITGB2 (0.65) | ITGB2ICAM1ITGALTMEM97 | |
| SCHEMBL27465304 | 0.86 | ITGB2 (0.65) | ITGB2ICAM1ITGALTMEM97 | |
| SCHEMBL13817021 | 0.85 | ITGB2 (0.78) | ITGB2ICAM1ITGAL | |
| SCHEMBL4020179 | 0.85 | ITGB2 (0.66) | ITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7550494-B2 | Small molecules useful in the treatment of inflammatory disease | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-7550494-B2 | Small molecules useful in the treatment of inflammatory disease | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-7462637-B2 | Derivatives of [6,7-dihydro-5H-imidazo[1,2--a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-12-09 | — | — | US | disclosed |
| EP-1216247-B1 | IMIDAZOIMIDAZOLES AND TRIAZOLES AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMA (US) | 2008-11-05 | — | — | EP | disclosed |