Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 3/20 | 0.55 |
| ▸ | ITK | Q08881 | 3/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | GMNN | O75496 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL141486 | 0.90 | LCK (0.67) | LCKITKAURKBNPC1RAB9A | |
| SCHEMBL140313 | 0.88 | LCK (0.55) | LCKITKAURKBCSNK1DNPC1 | |
| SCHEMBL143889 | 0.85 | LCK (0.49) | LCKITKAURKBDYRK1ANPC1 | |
| SCHEMBL138887 | 0.84 | RAB9A (0.52) | LCKITKAURKBNPC1RAB9A | |
| SCHEMBL136247 | 0.77 | LCK (0.67) | LCKITKAURKBNPC1RAB9A | |
| SCHEMBL144539 | 0.76 | MAPT (0.55) | LCKITKAURKBDYRK1ANPC1 | |
| SCHEMBL138175 | 0.76 | CSNK1D (0.46) | LCKITKAURKBDYRK1ACSNK1D | |
| SCHEMBL142375 | 0.73 | LCK (0.69) | LCKITKAURKBDYRK1ACSNK1D | |
| SCHEMBL140467 | 0.73 | DYRK1A (0.51) | LCKITKAURKBDYRK1ACSNK1D | |
| SCHEMBL144811 | 0.73 | LCK (0.68) | LCKITKAURKBDYRK1ACSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058984-A1 | PYRIMIDINE DERIVATIVES USED AS ITK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058984-A1 | PYRIMIDINE DERIVATIVES USED AS ITK INHIBITORS | DTYMK, ITK, DCK | LCK 189/4885ITK 2/4885AURKB 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.