Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 18/20 | 0.83 |
| ▸ | FKBP4 | Q02790 | 2/20 | 0.83 |
| ▸ | PPP3CA | Q08209 | 2/20 | 0.83 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.83 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.83 |
| ▸ | MLNR | O43193 | 1/20 | 0.83 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.83 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.83 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.83 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.83 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.83 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.83 |
| ▸ | HTR2A | P28223 | 1/20 | 0.83 |
| ▸ | HTR2B | P41595 | 1/20 | 0.83 |
| ▸ | MTOR | P42345 | 1/20 | 0.83 |
| ▸ | FKBP1B | P68106 | 1/20 | 0.83 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.83 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.83 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13817850 | 0.95 | FKBP1A (0.82) | FKBP1AFKBP4PPP3CAABCB11ADORA3 | |
| SCHEMBL15258615 | 0.95 | FKBP1A (0.80) | FKBP1AFKBP4PPP3CAABCB11ADORA3 | |
| SCHEMBL21728972 | 0.95 | FKBP1A (0.80) | FKBP1AFKBP4PPP3CAABCB11ADORA3 | |
| SCHEMBL18233842 | 0.95 | FKBP1A (0.80) | FKBP1AFKBP4PPP3CAABCB11ADORA3 | |
| SCHEMBL25083214 | 0.95 | FKBP1A (0.81) | FKBP1AFKBP4PPP3CAABCB11ADORA3 | |
| SCHEMBL15299563 | 0.94 | FKBP1A (0.80) | FKBP1AFKBP4PPP3CAABCB11ADORA3 | |
| SCHEMBL16907068 | 0.94 | FKBP1A (0.91) | FKBP1AFKBP4PPP3CAABCB11ADORA3 | |
| SCHEMBL9696142 | 0.94 | FKBP1A (0.82) | FKBP1AFKBP4PPP3CAABCB11ADORA3 | |
| SCHEMBL18233848 | 0.93 | FKBP1A (0.79) | FKBP1AFKBP4PPP3CAABCB11ADORA3 | |
| SCHEMBL13817933 | 0.93 | FKBP1A (0.89) | FKBP1AFKBP4PPP3CAABCB11ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11000514-B2 | Antifungal compounds | DUKE UNIVERSITY (US) | 2021-05-11 | — | — | US | disclosed |
| US-20200188364-A1 | ANTIFUNGAL COMPOUNDS | DUKE UNIVERSITY | 2020-06-18 | — | — | US | disclosed |
| US-10568872-B2 | Antifungal compounds | DUKE UNIVERSITY (US) | 2020-02-25 | — | — | US | disclosed |
| US-20190000814-A1 | Antifungal Compounds | AMPLYX PHARMACEUTICALS, INC. (US) | 2019-01-03 | — | — | US | disclosed |
| US-9956207-B2 | Antifungal compounds | AMPLYX PHARMACEUTICALS, INC. (US) | 2018-05-01 | — | — | US | disclosed |
| US-9956207-B2 | Antifungal compounds | AMPLYX PHARMACEUTICALS, INC. (US) | 2018-05-01 | — | — | US | disclosed |
| US-20160331730-A1 | Antifungal Compounds | AMPLYX PHARMACEUTICALS, INC. (US) | 2016-11-17 | — | — | US | disclosed |
| US-20160331730-A1 | Antifungal Compounds | AMPLYX PHARMACEUTICALS, INC. (US) | 2016-11-17 | — | — | US | disclosed |
| WO-2015106283-A1 | ANTIFUNGAL COMPOUNDS | AMPLYX PHARMACEUTICALS, INC. (US) | 2015-07-16 | — | — | WO | disclosed |
| US-7553842-B2 | Macrocyclic analogs for the treatment of immunoregulatory disorders and respiratory diseases | ARRAY BIOPHARMA INC. (US) | 2009-06-30 | — | — | US | disclosed |
| US-7553842-B2 | Macrocyclic analogs for the treatment of immunoregulatory disorders and respiratory diseases | ARRAY BIOPHARMA INC. (US) | 2009-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160331730-A1 | Antifungal Compounds | ERG28, DPM1, CYP51A1 | FKBP1A 997/4885FKBP4 807/4885PPP3CA 2546/4885 |
| US-10568872-B2 | Antifungal compounds | ERG28, DPM1, CYP51A1 | FKBP1A 997/4885FKBP4 807/4885PPP3CA 2546/4885 |
| US-20190000814-A1 | Antifungal Compounds | ERG28, DPM1, CYP51A1 | FKBP1A 997/4885FKBP4 807/4885PPP3CA 2546/4885 |
| US-11000514-B2 | Antifungal compounds | ERG28, DPM1, CYP51A1 | FKBP1A 997/4885FKBP4 807/4885PPP3CA 2546/4885 |
| US-20200188364-A1 | ANTIFUNGAL COMPOUNDS | ERG28, DPM1, CYP51A1 | FKBP1A 997/4885FKBP4 807/4885PPP3CA 2546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.