Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.49 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | CDC25A | P30304 | 1/20 | 0.40 |
| ▸ | CDC25C | P30307 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 2/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13819449 | 0.82 | CDK5 (0.43) | CDK5CDK5R1FEN1KDM4EALDH1A1 | |
| SCHEMBL3508562 | 0.82 | CDK5 (0.43) | CDK5CDK5R1FEN1KDM4EALDH1A1 | |
| SCHEMBL3506366 | 0.79 | CLK1 (0.50) | CDK5CDK5R1FEN1KDM4EALDH1A1 | |
| SCHEMBL5879244 | 0.73 | CHEK1 (0.59) | CDK5CDK5R1FEN1KDM4EALDH1A1 | |
| SCHEMBL797858 | 0.72 | KDM4E (0.50) | FEN1KDM4EALDH1A1GLAGAA | |
| SCHEMBL3251991 | 0.70 | KDM4E (0.58) | CDK5CDK5R1FEN1KDM4EALDH1A1 | |
| SCHEMBL13417447 | 0.70 | KDM4E (0.65) | CDK5CDK5R1FEN1KDM4EALDH1A1 | |
| SCHEMBL22566960 | 0.69 | CDK4 (0.71) | CDK5CDK5R1CDK4CCND1CCNE2 | |
| SCHEMBL5821446 | 0.68 | ROCK2 (0.52) | CDK5CDK5R1 | |
| SCHEMBL17613784 | 0.66 | CDK5 (0.47) | CDK5CDK5R1FEN1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009075830-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2009-06-18 | — | — | WO | disclosed |