Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 10/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 7/20 | 0.41 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2657168 | 0.83 | CYP1A2 (0.54) | TRPV4RAB9AMAPTNPC1GAA | |
| SCHEMBL2657744 | 0.76 | MAPT (0.44) | TRPV4RAB9AMAPTNPC1MEN1 | |
| SCHEMBL2656650 | 0.75 | GCK (0.50) | RAB9AMAPTNPC1MEN1KMT2A | |
| SCHEMBL1831608 | 0.74 | MAPT (0.40) | RAB9AMAPTNPC1MEN1KMT2A | |
| SCHEMBL3028524 | 0.73 | MEN1 (0.50) | RAB9AMAPTNPC1MEN1KMT2A | |
| SCHEMBL3043516 | 0.72 | GAA (0.51) | RAB9AMAPTNPC1MEN1KMT2A | |
| SCHEMBL8986532 | 0.72 | RAB9A (0.59) | RAB9AMAPTNPC1MEN1KMT2A | |
| SCHEMBL2669599 | 0.71 | CCNK (0.42) | RAB9AMAPTNPC1MEN1KMT2A | |
| SCHEMBL14742578 | 0.71 | CYP1A2 (0.56) | TRPV4RAB9AMAPTNPC1MEN1 | |
| SCHEMBL5230966 | 0.70 | SMN1; SMN2 (0.43) | RAB9AMAPTNPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195312-B1 | PYRIDINE DERIVATIVES USEFUL AS GLUCOKINASE ACTIVATORS | MERCK PATENT GMBH (DE) | 2012-11-21 | — | — | EP | claimed |