Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | RAB9A | P51151 | 7/20 | 0.43 |
| ▸ | NPC1 | O15118 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | GCK | P35557 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 2/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2657937 | 0.81 | MAPT (0.53) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL3043516 | 0.81 | GAA (0.51) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL2669599 | 0.80 | CCNK (0.42) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL2657411 | 0.79 | MEN1 (0.40) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL2657168 | 0.77 | CYP1A2 (0.54) | MAPTRAB9ANPC1SMN1; SMN2GAA | |
| SCHEMBL28784584 | 0.76 | MEN1 (0.39) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL13822801 | 0.76 | TRPV4 (0.47) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL3028524 | 0.74 | MEN1 (0.50) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL1063890 | 0.74 | ALDH1A1 (0.42) | MAPTRAB9ANPC1ALDH1A1KDM4E | |
| SCHEMBL29630882 | 0.74 | ALDH1A1 (0.42) | MAPTRAB9ANPC1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195312-B1 | PYRIDINE DERIVATIVES USEFUL AS GLUCOKINASE ACTIVATORS | MERCK PATENT GMBH (DE) | 2012-11-21 | — | — | EP | claimed |
| US-8420642-B2 | Pyridine derivatives useful as glucokinase activators | MERCK PATENT GMBH (DE) | 2013-04-16 | — | — | US | disclosed |
| US-8420642-B2 | Pyridine derivatives useful as glucokinase activators | MERCK PATENT GMBH (DE) | 2013-04-16 | — | — | US | disclosed |
| US-8420642-B2 | Pyridine derivatives useful as glucokinase activators | MERCK PATENT GMBH (DE) | 2013-04-16 | — | — | US | disclosed |
| EP-2195312-B1 | PYRIDINE DERIVATIVES USEFUL AS GLUCOKINASE ACTIVATORS | MERCK PATENT GMBH (DE) | 2012-11-21 | — | — | EP | disclosed |
| EP-2195312-B1 | PYRIDINE DERIVATIVES USEFUL AS GLUCOKINASE ACTIVATORS | MERCK PATENT GMBH (DE) | 2012-11-21 | — | — | EP | disclosed |
| US-20100216794-A1 | PYRIDINE DERIVATIVES USEFUL AS GLUCOKINASE ACTIVATORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-08-26 | — | — | US | disclosed |
| US-20100216794-A1 | PYRIDINE DERIVATIVES USEFUL AS GLUCOKINASE ACTIVATORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-08-26 | — | — | US | disclosed |
| US-20100216794-A1 | PYRIDINE DERIVATIVES USEFUL AS GLUCOKINASE ACTIVATORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-08-26 | — | — | US | disclosed |
| EP-2195312-A1 | PYRIDINE DERIVATIVES USEFUL AS GLUCOKINASE ACTIVATORS | Merck Patent GmbH (DE) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009046784-A1 | PYRIDINE DERIVATIVES USEFUL AS GLUCOKINASE ACTIVATORS | MERCK PATENT GMBH (DE) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009046784-A1 | PYRIDINE DERIVATIVES USEFUL AS GLUCOKINASE ACTIVATORS | MERCK PATENT GMBH (DE) | 2009-04-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216794-A1 | PYRIDINE DERIVATIVES USEFUL AS GLUCOKINASE ACTIVATORS | HK1, GCKR, GCK | MAPT 2751/4885RAB9A 3858/4885NPC1 2816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.