SCHEMBL13824178

SCHEMBL13824178

COc1ccc(C2(c3ccc(OC)cc3)C=Cc3c4c(c5ccccc5c3O2)-c2ccccc2C4(C)OCCOC(=O)CCC(=O)O)cc1

nearest known ligand 0.35

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.33
ALDH1A1 P00352 3/20 0.32
LMNA P02545 1/20 0.32
HTT P42858 1/20 0.32
PDK2 Q15119 1/20 0.30
KIF11 P52732 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15470691 0.95 HTT (0.32) TP53ALDH1A1LMNAHTT
SCHEMBL15470692 0.95 HTT (0.32) TP53ALDH1A1LMNAHTT
SCHEMBL15470689 0.94 PDK2 (0.34) TP53ALDH1A1LMNAHTTPDK2
SCHEMBL15445521 0.94 HTT (0.32) TP53ALDH1A1LMNAHTT
SCHEMBL14232865 0.92 HTT (0.31) TP53HTT
SCHEMBL17479893 0.92 HTT (0.31) TP53HTT
SCHEMBL15445493 0.92 PDK2 (0.31) TP53HTTPDK2
SCHEMBL22239340 0.92 ALK (0.32) HTT
SCHEMBL13824173 0.91 HTT (0.33) HTT
SCHEMBL15445506 0.91 HTT (0.31) TP53HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2714767-B1 PHOTOCHROMIC POLYMERS VIVIMED LABS EUROPE LTD (GB) 2020-07-22 EP disclosed
EP-2705071-B1 PHOTOCHROMIC POLYMER VIVIMED LABS EUROPE LTD (GB) 2017-03-08 EP disclosed
US-9250356-B2 Photochromic polymers VIVIMED LABS EUROPE LTD (GB) 2016-02-02 US disclosed
US-9250356-B2 Photochromic polymers VIVIMED LABS EUROPE LTD (GB) 2016-02-02 US disclosed
US-9217812-B2 Photochromic polymer VIVIMED LABS EUROPE LTD (GB) 2015-12-22 US disclosed
US-9217812-B2 Photochromic polymer VIVIMED LABS EUROPE LTD (GB) 2015-12-22 US disclosed
US-20140042377-A1 Photochromic Polymer VIVIMED LABS EUROPE LTD (GB) 2014-02-13 US disclosed
US-20140042377-A1 Photochromic Polymer VIVIMED LABS EUROPE LTD (GB) 2014-02-13 US disclosed
US-20140027684-A1 PHOTOCHROMIC POLYMERS VIVIMED LABS EUROPE LTD (GB) 2014-01-30 US disclosed
US-20140027684-A1 PHOTOCHROMIC POLYMERS VIVIMED LABS EUROPE LTD (GB) 2014-01-30 US disclosed
WO-2012162725-A1 PHOTOCHROMIC POLYMERS ADVANCED POLYMERIK PTY LTD (AU) 2012-12-06 WO disclosed
WO-2012149599-A1 PHOTOCHROMIC POLYMER ADVANCED POLYMERIK PTY LTD (AU) 2012-11-08 WO disclosed