Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8165999 | 0.81 | ALDH1A1 (0.39) | TSHRHTR2AHTR2CHTR2BMAPT | |
| SCHEMBL8280908 | 0.80 | FFAR4 (0.43) | TSHRHTR2AHTR2CHTR2BCSNK2A1 | |
| SCHEMBL12269156 | 0.79 | CSNK2A1 (0.56) | CSNK2A1RORCSMN1; SMN2 | |
| SCHEMBL23602742 | 0.79 | KCNQ3 (0.39) | CSNK2A1MAPTRORCPPARGPPARA | |
| SCHEMBL16606251 | 0.78 | ALDH1A1 (0.46) | TSHRHTR2AHTR2CHTR2BCSNK2A1 | |
| Water SCHEMBL27734654 | 0.78 | CSNK2A1 (0.54) | CSNK2A1RORCSMN1; SMN2 | |
| SCHEMBL3365122 | 0.77 | LMNA (0.47) | TSHRHTR2AHTR2CHTR2BCSNK2A1 | |
| SCHEMBL2284093 | 0.77 | ALDH1A1 (0.43) | TSHRHTR2AHTR2CHTR2BCSNK2A1 | |
| SCHEMBL3716834 | 0.77 | HTR2B (0.42) | TSHRHTR2AHTR2CHTR2BCSNK2A1 | |
| SCHEMBL12569380 | 0.77 | SLC6A4 (0.41) | TSHRHTR2AHTR2CHTR2BCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245019-B1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-11-14 | — | — | EP | disclosed |