Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 4/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16002874 | 0.88 | SIGMAR1 (0.54) | SIGMAR1KMT2ASYKCA2CA1 | |
| SCHEMBL13826054 | 0.86 | SYK (0.47) | SIGMAR1SYK | |
| SCHEMBL13826435 | 0.84 | HPGD (0.53) | KMT2A | |
| SCHEMBL13826668 | 0.82 | ALDH1A1 (0.50) | SIGMAR1 | |
| SCHEMBL13826667 | 0.82 | EPHX2 (0.53) | SIGMAR1KMT2ASYKOPRK1 | |
| SCHEMBL6568665 | 0.82 | KMT2A (0.60) | SIGMAR1KMT2ACA2CA1OPRK1 | |
| SCHEMBL6567577 | 0.81 | KMT2A (0.58) | SIGMAR1KMT2ACA2CA1OPRK1 | |
| SCHEMBL16000507 | 0.81 | POLB (0.51) | SIGMAR1KMT2ASYKOPRK1 | |
| SCHEMBL13825978 | 0.80 | HDAC3 (0.53) | SIGMAR1KMT2ASYK | |
| SCHEMBL16000496 | 0.77 | SMN1; SMN2 (0.53) | SIGMAR1KMT2ASYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9145391-B2 | Bipyridylaminopyridines as Syk inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-09-29 | — | — | US | disclosed |
| US-20140249130-A1 | BIPYRIDYLAMINOPYRIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME LLC | 2014-09-04 | — | — | US | disclosed |
| WO-2012154518-A1 | BIPYRIDYLAMINOPYRIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140249130-A1 | BIPYRIDYLAMINOPYRIDINES AS SYK INHIBITORS | SYK, BTK, LCK | SIGMAR1 2509/4885KMT2A 2649/4885SYK 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.