Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 14/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 14/20 | 0.58 |
| ▸ | PRKDC | P78527 | 14/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 13/20 | 0.58 |
| ▸ | ABL1 | P00519 | 11/20 | 0.58 |
| ▸ | EGFR | P00533 | 11/20 | 0.58 |
| ▸ | HCK | P08631 | 11/20 | 0.58 |
| ▸ | SRC | P12931 | 11/20 | 0.58 |
| ▸ | MTOR | P42345 | 11/20 | 0.58 |
| ▸ | EPHB4 | P54760 | 11/20 | 0.58 |
| ▸ | KDR | P35968 | 10/20 | 0.58 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.53 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.53 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL130502 | 0.85 | PIK3CD (0.60) | PIK3CDPIK3CAPIK3CBPRKDCPIK3CG | |
| SCHEMBL130503 | 0.84 | PIK3CD (0.60) | PIK3CDPIK3CAPIK3CBPRKDCPIK3CG | |
| SCHEMBL130618 | 0.82 | PIK3CD (0.68) | PIK3CDPIK3CAPIK3CBPRKDCPIK3CG | |
| SCHEMBL129581 | 0.81 | PIK3CD (0.59) | PIK3CDPIK3CAPIK3CBPRKDCPIK3CG | |
| SCHEMBL13826048 | 0.81 | NUDT14 (0.63) | PIK3CDPIK3CAPIK3CBPRKDCPIK3CG | |
| SCHEMBL23917419 | 0.77 | PIK3CD (0.60) | PIK3CDPIK3CAPIK3CBPRKDCPIK3CG | |
| SCHEMBL128512 | 0.77 | PIK3CD (0.60) | PIK3CDPIK3CAPIK3CBPRKDCPIK3CG | |
| SCHEMBL18874071 | 0.77 | PIK3CD (0.65) | PIK3CDPIK3CAPIK3CBPRKDCPIK3CG | |
| SCHEMBL409367 | 0.77 | PIK3CD (0.82) | PIK3CDPIK3CAPIK3CBPRKDCPIK3CG | |
| SCHEMBL12366 | 0.77 | NUDT14 (0.69) | PIK3CDPIK3CAPIK3CBPRKDCPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012151525-A9 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | RHIZEN PHARMACEUTICALS SA (CH) | 2012-12-13 | — | — | WO | disclosed |
| WO-2012151525-A1 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | RHIZEN PHARMACEUTICALS SA (CH) | 2012-11-08 | — | — | WO | disclosed |