Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 11/20 | 0.82 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.82 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.82 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.82 |
| ▸ | PRKDC | P78527 | 11/20 | 0.82 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.78 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.78 |
| ▸ | SRC | P12931 | 13/20 | 0.71 |
| ▸ | ABL1 | P00519 | 9/20 | 0.71 |
| ▸ | EGFR | P00533 | 9/20 | 0.71 |
| ▸ | HCK | P08631 | 8/20 | 0.71 |
| ▸ | MTOR | P42345 | 8/20 | 0.71 |
| ▸ | EPHB4 | P54760 | 8/20 | 0.71 |
| ▸ | KDR | P35968 | 7/20 | 0.71 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.61 |
| ▸ | FYN | P06241 | 2/20 | 0.60 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL130529 | 0.88 | NUDT14 (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL30782445 | 0.88 | NUDT14 (0.69) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL12366 | 0.88 | NUDT14 (0.69) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL23917506 | 0.86 | NUDT14 (0.64) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL13826003 | 0.86 | SRC (0.68) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL130421 | 0.85 | PIK3CD (0.78) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL21079131 | 0.85 | NUDT14 (0.66) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL130419 | 0.85 | PIK3CD (0.70) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL23917243 | 0.85 | KDM4E (0.69) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL13019672 | 0.85 | SRC (0.69) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10844038-B2 | 1,2-dithiolane compounds useful in neuroprotection, autoimmune and cancer diseases and conditions | SABILA BIOSCIENCES LLC (US) | 2020-11-24 | — | — | US | disclosed |
| US-RE48175-E1 | Hydrophobically tagged small molecules as inducers of protein degradation | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-08-25 | — | — | US | disclosed |
| US-20180093990-A1 | HYDROPHOBICALLY TAGGED SMALL MOLECULES AS INDUCERS OF PROTEIN DEGRADATION | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-04-05 | — | — | US | disclosed |
| US-9758522-B2 | Hydrophobically tagged small molecules as inducers of protein degradation | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-09-12 | — | — | US | disclosed |
| US-9580427-B2 | Kinase inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-02-28 | — | — | US | disclosed |
| US-20160168151-A1 | PYRAZOLO PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-06-16 | — | — | US | disclosed |
| US-20150031881-A1 | PYRAZOLO PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-01-29 | — | — | US | disclosed |
| US-20140323464-A1 | KINASE INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-10-30 | — | — | US | disclosed |
| US-20120065154-A1 | Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-03-15 | — | — | US | disclosed |
| US-20090181988-A1 | Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168151-A1 | PYRAZOLO PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF | DPYD, DHODH, DLD | PIK3CD 2019/4885PIK3CA 1473/4885PIK3CB 1902/4885 |
| US-20140323464-A1 | KINASE INHIBITORS | MAP3K20, MAP3K19, MAP3K1 | PIK3CD 214/4885PIK3CA 121/4885PIK3CB 160/4885 |
| US-20150031881-A1 | PYRAZOLO PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF | DPYD, DHODH, DLD | PIK3CD 2019/4885PIK3CA 1473/4885PIK3CB 1902/4885 |
| US-20090181988-A1 | Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof | DPYD, DHODH, DLD | PIK3CD 2019/4885PIK3CA 1473/4885PIK3CB 1902/4885 |
| US-20120065154-A1 | Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof | DPYD, DHODH, DLD | PIK3CD 2019/4885PIK3CA 1473/4885PIK3CB 1902/4885 |
| US-10844038-B2 | 1,2-dithiolane compounds useful in neuroprotection, autoimmune and cancer diseases and conditions | BTK, FYN, YES1 | PIK3CD 191/4885PIK3CA 186/4885PIK3CB 365/4885 |
| US-20180093990-A1 | HYDROPHOBICALLY TAGGED SMALL MOLECULES AS INDUCERS OF PROTEIN DEGRADATION | MYC, TP53, MDM2 | PIK3CD 3060/4885PIK3CA 2420/4885PIK3CB 2678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.