Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 11/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19017856 | 0.88 | KDM4E (0.45) | KDM4EPTGDR2MEN1ALDH1A1KMT2A | |
| SCHEMBL19017855 | 0.85 | PTGDR2 (0.52) | KDM4EPTGDR2MEN1ALDH1A1KMT2A | |
| SCHEMBL13734032 | 0.82 | TLR8 (0.34) | DPP4KDM4EPTGDR2MEN1ALDH1A1 | |
| SCHEMBL13826237 | 0.81 | KDM4E (0.44) | KDM4EPTGDR2MEN1ALDH1A1KMT2A | |
| SCHEMBL19017857 | 0.79 | PTGDR2 (0.44) | KDM4EPTGDR2MEN1ALDH1A1KMT2A | |
| SCHEMBL19906092 | 0.78 | PTGDR2 (0.48) | KDM4EPTGDR2MEN1ALDH1A1KMT2A | |
| SCHEMBL13735716 | 0.78 | CYP3A4 (0.45) | DPP4DPP8 | |
| SCHEMBL19017848 | 0.77 | TLR8 (0.43) | DPP4KDM4EALDH1A1DPP8 | |
| SCHEMBL19906055 | 0.77 | PTGDR2 (0.38) | KDM4EPTGDR2MEN1ALDH1A1KMT2A | |
| SCHEMBL19017872 | 0.76 | KDM4E (0.40) | KDM4EPTGDR2MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3181555-A1 | BENZOTHIAZOLE COMPOUNDS AND THEIR PHARMACEUTICAL USE | Gilead Sciences, Inc. (US) | 2017-06-21 | — | — | EP | disclosed |
| WO-2012145728-A1 | BENZOTHIAZOLE COMPOUNDS AND THEIR PHARMACEUTICAL USE | GILEAD SCIENCES, INC. (US) | 2012-10-26 | — | — | WO | disclosed |