Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13719183 | 0.86 | RET (0.47) | MAPTCYP19A1NPC1RAB9AMAOB | |
| SCHEMBL4224331 | 0.78 | MAPT (0.52) | MAPTCYP19A1NPC1RAB9AMAOB | |
| SCHEMBL11256026 | 0.74 | MAPT (0.51) | MAPTCYP19A1NPC1RAB9AMAOB | |
| SCHEMBL14895951 | 0.71 | MAPT (0.63) | MAPTCYP19A1NPC1RAB9AMAOB | |
| SCHEMBL1893757 | 0.71 | MAPT (0.50) | MAPTCYP19A1NPC1RAB9AMAOB | |
| SCHEMBL29209376 | 0.71 | MAPT (0.47) | MAPTCYP19A1NPC1RAB9AMAOB | |
| SCHEMBL1893755 | 0.71 | MAPT (0.50) | MAPTCYP19A1NPC1RAB9AMAOB | |
| SCHEMBL30638795 | 0.70 | CYP19A1 (0.57) | CYP19A1MAOBSMN1; SMN2ABCB1AR | |
| SCHEMBL29397268 | 0.70 | CYP19A1 (0.57) | CYP19A1MAOBSMN1; SMN2ABCB1AR | |
| SCHEMBL17637164 | 0.70 | KDM4E (0.58) | MAPTCYP19A1NPC1RAB9AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296717-B2 | Synthesis of C-3 coupled biflavonoids and C-3 coupled biflavonoid analogues | UNIVERSITY OF THE FREE STATE (ZA) | 2016-03-29 | — | — | US | disclosed |
| US-9296717-B2 | Synthesis of C-3 coupled biflavonoids and C-3 coupled biflavonoid analogues | UNIVERSITY OF THE FREE STATE (ZA) | 2016-03-29 | — | — | US | disclosed |
| US-20120289715-A1 | Synthesis of C-3 Coupled Biflavonoids and C-3 Coupled Biflavonoid Analogues | UNIVERSITY OF THE FREE STATE (ZA) | 2012-11-15 | — | — | US | disclosed |
| US-20120289715-A1 | Synthesis of C-3 Coupled Biflavonoids and C-3 Coupled Biflavonoid Analogues | UNIVERSITY OF THE FREE STATE (ZA) | 2012-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120289715-A1 | Synthesis of C-3 Coupled Biflavonoids and C-3 Coupled Biflavonoid Analogues | CBR3, C9, PROC | MAPT 4751/4885CYP19A1 481/4885NPC1 2881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.