Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1383365 | 0.85 | GAA (0.53) | GAAALOX15ALDH1A1TSHRMAPK1 | |
| SCHEMBL1382337 | 0.79 | FABP1 (0.45) | ALOX15ALDH1A1TSHRMAPK1GFER | |
| SCHEMBL1382193 | 0.79 | PKM (0.51) | GAAALOX15ALDH1A1TSHRMAPK1 | |
| SCHEMBL1381205 | 0.76 | ALOX15 (0.43) | GAAALOX15ALDH1A1TSHRMAPK1 | |
| SCHEMBL1382942 | 0.75 | GAA (0.56) | GAAALOX15ALDH1A1TSHRMAPK1 | |
| SCHEMBL4208499 | 0.72 | GAA (0.47) | GAAALDH1A1TSHRMAPK1GFER | |
| SCHEMBL4033096 | 0.71 | GAA (0.60) | GAAALDH1A1TSHRMAPK1GFER | |
| SCHEMBL1383367 | 0.70 | GAA (0.58) | GAAALOX15ALDH1A1TSHRMAPK1 | |
| SCHEMBL4037678 | 0.69 | GAA (0.46) | GAAALDH1A1TSHRMAPK1MAPT | |
| SCHEMBL4037109 | 0.69 | GAA (0.57) | GAAALOX15ALDH1A1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4825664-B2 | — | — | 2011-11-30 | — | — | JP | claimed |
| EP-1592389-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | Applied Research Systems ARS Holding N.V. (AN) | 2005-11-09 | — | — | EP | claimed |
| WO-2004071390-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2004-08-26 | — | — | WO | claimed |
| EP-1592389-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | Applied Research Systems ARS Holding N.V. (AN) | 2005-11-09 | — | — | EP | disclosed |
| WO-2004071390-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2004-08-26 | — | — | WO | disclosed |