Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | PNP | P00491 | 2/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | QTRT1 | Q9BXR0 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 3/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29774108 | 0.83 | PDE5A (0.37) | KDM4EALDH1A1HSD17B10THRBMEN1 | |
| SCHEMBL26018337 | 0.79 | PDE5A (0.44) | MEN1KMT2APDE5A | |
| SCHEMBL12102096 | 0.79 | PDE5A (0.47) | KDM4EALDH1A1HSD17B10MAPTHPGD | |
| SCHEMBL1623385 | 0.78 | PDE5A (0.44) | PDE5A | |
| SCHEMBL3663889 | 0.77 | PDE5A (0.41) | PDE5AAKR1B1 | |
| SCHEMBL5632 | 0.73 | NUDT1 (0.50) | KDM4EALDH1A1HSD17B10THRBMEN1 | |
| SCHEMBL30388675 | 0.73 | NUDT1 (0.50) | KDM4EALDH1A1HSD17B10THRBMEN1 | |
| SCHEMBL13916085 | 0.72 | CYP1A2 (0.51) | KDM4EALDH1A1HSD17B10THRBMEN1 | |
| SCHEMBL10813052 | 0.72 | CYP1A2 (0.59) | KDM4EALDH1A1HSD17B10THRBMEN1 | |
| SCHEMBL744451 | 0.72 | CYP1A2 (0.48) | KDM4EALDH1A1HSD17B10THRBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220090096-A1 | GENETIC CONSTRUCT | UNIV NOTTINGHAM (GB) | 2022-03-24 | — | — | US | disclosed |
| EP-2707487-B1 | RIBOSWITCHES | UNIV MANCHESTER (GB) | 2017-10-04 | — | — | EP | disclosed |
| US-20140213779-A1 | RIBOSWITCHES | THE UNIVERSITY OF MANCHESTER (GB) | 2014-07-31 | — | — | US | disclosed |
| US-20140213779-A1 | RIBOSWITCHES | THE UNIVERSITY OF MANCHESTER (GB) | 2014-07-31 | — | — | US | disclosed |
| WO-2012153142-A2 | RIBOSWITCHES | THE UNIVERSITY OF MANCHESTER (GB) | 2012-11-15 | — | — | WO | disclosed |