Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.47 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15101513 | 0.92 | ADORA1 (0.55) | LMNADRD4ADORA1DRD2DRD3 | |
| SCHEMBL13833586 | 0.83 | LMNA (0.60) | LMNARXFP1APEX1MEN1MAPT | |
| SCHEMBL13833692 | 0.82 | APEX1 (0.69) | LMNARXFP1APEX1MEN1MAPT | |
| SCHEMBL3752414 | 0.78 | APEX1 (0.66) | LMNARXFP1APEX1MEN1MAPT | |
| SCHEMBL18293135 | 0.75 | KDM4E (0.47) | LMNAAPEX1MEN1MAPTKMT2A | |
| SCHEMBL13737316 | 0.75 | APEX1 (0.67) | APEX1MEN1MAPTKMT2A | |
| SCHEMBL13833662 | 0.75 | ILK (0.48) | APEX1MEN1MAPTKMT2A | |
| SCHEMBL14778519 | 0.74 | KDM4E (0.55) | LMNARXFP1APEX1MEN1MAPT | |
| Hydrochloric Acid SCHEMBL14777604 | 0.74 | ILK (0.47) | APEX1MEN1MAPTKMT2A | |
| SCHEMBL1494800 | 0.74 | APEX1 (0.73) | LMNAAPEX1MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012154888-A1 | COMPOUNDS FOR TREATING PROTEIN FOLDING DISORDERS | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2012-11-15 | — | — | WO | disclosed |