Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13834856 | 1.00 | NOTUM (0.32) | NOTUMHTR2AHTR2CSLC6A4HTR2B | |
| SCHEMBL6900223 | 0.84 | KDM1A (0.32) | — | |
| SCHEMBL13834925 | 0.84 | KDM1A (0.32) | — | |
| SCHEMBL13834465 | 0.81 | PGR (0.30) | — | |
| SCHEMBL1984892 | 0.81 | PGR (0.30) | — | |
| SCHEMBL13834431 | 0.81 | NOS3 (0.33) | NOTUMHTR2AHTR2CHTR2B | |
| SCHEMBL6899425 | 0.81 | NOS3 (0.33) | NOTUMHTR2AHTR2CHTR2B | |
| SCHEMBL31358091 | 0.80 | NOTUM (0.34) | NOTUMHTR2AHTR2CSLC6A4HTR2B | |
| SCHEMBL6899312 | 0.74 | PSMB8 (0.39) | NOTUMHTR2AHTR2CHTR2B | |
| SCHEMBL13834753 | 0.72 | UGT2B17 (0.32) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509950-B1 | 5-Amino-4-hydroxypentoyl amides | JANSSEN R & D IRELAND (IE) | 2015-02-25 | — | — | EP | disclosed |
| US-8592429-B2 | 5-amino-4-hydroxypentoyl amides | JANSSEN R&D IRELAND (IE) | 2013-11-26 | — | — | US | disclosed |
| US-20120295920-A1 | 5-AMINO-4-HYDROXYPENTOYL AMIDES | JANSSEN SCIENCES IRELAND UC (IE) | 2012-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120295920-A1 | 5-AMINO-4-HYDROXYPENTOYL AMIDES | C1S, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, H1-10 | NOTUM 2148/4885HTR2A 3146/4885HTR2C 2154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.