Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 7/20 | 0.39 |
| ▸ | PRKG1 | Q13976 | 6/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 4/20 | 0.39 |
| ▸ | PRKACA | P17612 | 4/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.39 |
| ▸ | CDK2 | P24941 | 4/20 | 0.39 |
| ▸ | AKT2 | P31751 | 4/20 | 0.39 |
| ▸ | GSK3A | P49840 | 4/20 | 0.39 |
| ▸ | GSK3B | P49841 | 4/20 | 0.39 |
| ▸ | PRKX | P51817 | 4/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.39 |
| ▸ | PRKG2 | Q13237 | 4/20 | 0.39 |
| ▸ | PKN2 | Q16513 | 4/20 | 0.39 |
| ▸ | CDC42BPA | Q5VT25 | 4/20 | 0.39 |
| ▸ | HIPK4 | Q8NE63 | 4/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.39 |
| ▸ | SGK2 | Q9HBY8 | 4/20 | 0.39 |
| ▸ | AKT1 | P31749 | 3/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27699505 | 0.72 | TRPV1 (0.38) | ROCK1PRKG1ROCK2CHRNA7 | |
| SCHEMBL1476869 | 0.72 | CHRNA7 (0.38) | ROCK1PRKG1MAPK1RPS6KA5PRKACA | |
| SCHEMBL1474347 | 0.72 | TRPV1 (0.38) | ROCK1PRKG1ROCK2CHRNA7 | |
| SCHEMBL5676107 | 0.58 | CHRNA7 (0.39) | PRKG1ROCK2DYRK1ACHRNA7 | |
| SCHEMBL5848169 | 0.58 | ACKR3 (0.42) | PRKG1ROCK2CYP3A4 | |
| SCHEMBL30824709 | 0.58 | ACKR3 (0.42) | PRKG1ROCK2CYP3A4 | |
| SCHEMBL30795745 | 0.58 | CHRNA7 (0.55) | PRKG1ROCK2CHRNA7CYP3A4 | |
| SCHEMBL5847724 | 0.58 | CHRNA7 (0.55) | PRKG1ROCK2CHRNA7CYP3A4 | |
| SCHEMBL1697493 | 0.58 | ACACB (0.64) | ROCK1PRKG1MAPK1RPS6KA5PRKACA | |
| SCHEMBL12827243 | 0.57 | KCNH2 (0.47) | PRKG1MAPK1ROCK2CHRNA7CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1861359-B1 | N-(N-SULFONYLAMINOMETHYL)CYCLOPROPANECARBOXAMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF PAIN | PFIZER (US) | 2012-11-14 | — | — | EP | disclosed |