SCHEMBL1383972

SCHEMBL1383972

[NH]c1cccc(Cl)c1F

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL320817 0.80
SCHEMBL30931747 0.72
SCHEMBL3004021 0.72
SCHEMBL1039840 0.72
SCHEMBL1807539 0.72
SCHEMBL55472 0.71
Phosphine SCHEMBL22230553 0.70 TAAR1 (0.46)
SCHEMBL19236964 0.70 ALDH1A1 (0.39)
SCHEMBL4573522 0.69 PNMT (0.41)
SCHEMBL80764 0.68

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2313377-B1 METHOD FOR STEREOSELECTIVE SYNTHESIS OF BICYCLIC HETEROCYCLES BOEHRINGER INGELHEIM INT (DE) 2016-01-06 EP claimed
CN-101128456-B Quinazoline derivatives as tyrosine kinase inhibitors ASTRAZENECA AB 2013-01-23 CN claimed
US-8263768-B2 Process for the stereoselective preparation of bicyclic heterocycles BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-09-11 US claimed
US-20120116080-A1 PROCESS FOR THE STEREOSELECTIVE PREPARATION OF BICYCLIC HETEROCYCLES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-05-10 US claimed
JP-4795952-B2 2011-10-19 JP claimed
CN-1914182-B Quinazoline derivatives ASTRAZENECA AB 2011-09-07 CN claimed
EP-1856095-B1 QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS ASTRAZENECA AB (SE) 2011-08-24 EP claimed
US-20110152297-A1 QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS Astra Zeneca AB Corporation 2011-06-23 US claimed
EP-2313377-A1 METHOD FOR STEREOSELECTIVE SYNTHESIS OF BICYCLIC HETEROCYCLENE BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-04-27 EP claimed
JP-4673839-B2 2011-04-20 JP claimed
WO-2006090163-A1 QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS ASTRAZENECA AB (SE) 2006-08-31 WO claimed
EP-1667996-A1 QUINAZOLINE DERIVATIVES Astrazeneca AB (SE) 2006-06-14 EP claimed
EP-1667991-A1 QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS Astrazeneca AB (SE) 2006-06-14 EP claimed
EP-1664030-A1 QUINAZOLINE DERIVATIVES AstraZeneca AB (SE) 2006-06-07 EP claimed
EP-1622620-A1 QUINAZOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER AstraZeneca AB (SE) 2006-02-08 EP claimed
WO-2005075439-A1 QUINAZOLINE DERIVATIVES ASTRAZENECA AB (SE) 2005-08-18 WO claimed
WO-2005026150-A1 QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS ASTRAZENECA AB (SE) 2005-03-24 WO claimed
WO-2005026156-A1 QUINAZOLINE DERIVATIVES ASTRAZENECA AB (SE) 2005-03-24 WO claimed
WO-2005026157-A1 QUINAZOLINE DERIVATIVES ASTRAZENECA AB (SE) 2005-03-24 WO claimed
WO-2004096226-A1 QUINAZOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER ASTRAZENECA AB (SE) 2004-11-11 WO claimed