Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | F10 | P00742 | 12/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1382423 | 0.83 | F10 (0.56) | F10 | |
| SCHEMBL17507085 | 0.80 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPTALDH1A1NPC1TP53 | |
| SCHEMBL7150779 | 0.80 | HTT (0.63) | SMN1; SMN2MAPTF10ATMALDH1A1 | |
| SCHEMBL7152058 | 0.79 | NAMPT (0.49) | SMN1; SMN2MAPTF10ALDH1A1HPGD | |
| SCHEMBL5443184 | 0.79 | MAPT (0.57) | SMN1; SMN2MAPTF10F2ALDH1A1 | |
| SCHEMBL7152000 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2MAPTF10ALDH1A1HPGD | |
| SCHEMBL15203335 | 0.77 | SMN1; SMN2 (0.59) | SMN1; SMN2MAPTF10F2ATM | |
| SCHEMBL17507082 | 0.77 | GAA (0.50) | SMN1; SMN2MAPTF10ALDH1A1HPGD | |
| SCHEMBL17541774 | 0.77 | GAA (0.50) | SMN1; SMN2MAPTF10ALDH1A1HPGD | |
| SCHEMBL7088328 | 0.76 | MAPT (0.68) | SMN1; SMN2MAPTF10ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4699985-B2 | — | — | 2011-06-15 | — | — | JP | claimed |
| EP-1585730-A1 | CARBOXAMIDE DERIVATIVES AND THEIR USE AS FACTOR XA INHIBITORS | MERCK PATENT GmbH (DE) | 2005-10-19 | — | — | EP | claimed |
| WO-2004065369-A1 | CARBOXAMIDE DERIVATIVES AND THEIR USE AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2004-08-05 | — | — | WO | claimed |