Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | F10 | P00742 | 3/20 | 0.49 |
| ▸ | FPR1 | P21462 | 1/20 | 0.48 |
| ▸ | FPR2 | P25090 | 1/20 | 0.48 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17507085 | 0.87 | SMN1; SMN2 (0.55) | HTTSMN1; SMN2MAPTUSP2NPC1 | |
| SCHEMBL1677937 | 0.84 | GAA (0.64) | POLBSMN1; SMN2MAPTNPC1ALDH1A1 | |
| SCHEMBL7152058 | 0.83 | NAMPT (0.49) | HTTSMN1; SMN2MAPTUSP2NPC1 | |
| SCHEMBL5443184 | 0.83 | MAPT (0.57) | HTTSMN1; SMN2MAPTALDH1A1TP53 | |
| SCHEMBL7152000 | 0.82 | SMN1; SMN2 (0.50) | HTTSMN1; SMN2MAPTUSP2NPC1 | |
| SCHEMBL7148309 | 0.82 | MAPT (0.68) | HTTPOLBSMN1; SMN2MAPTUSP2 | |
| SCHEMBL17541774 | 0.81 | GAA (0.50) | SMN1; SMN2MAPTNPC1ALDH1A1TP53 | |
| SCHEMBL7153529 | 0.81 | NPC1 (0.69) | HTTPOLBSMN1; SMN2MAPTUSP2 | |
| SCHEMBL7148434 | 0.81 | NPC1 (0.56) | SMN1; SMN2MAPTNPC1ALDH1A1TP53 | |
| SCHEMBL17507082 | 0.81 | GAA (0.50) | SMN1; SMN2MAPTNPC1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351938-A1 | PHENYL DERIVATIVES | MERCK PATENT GmbH (DE) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002057236-A1 | PHENYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2002-07-25 | — | — | WO | disclosed |